Jun Jin Woo, Han Jee Eun, Giri Sib Sankar, Tang Kathy F J, Zhou Xiaohui, Aranguren Luis Fernando, Kim Hyoun Joong, Yun Saekil, Chi Cheng, Kim Sang Guen, Park Se Chang
1Laboratory of Aquatic Biomedicine, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, 151-742 Republic of Korea.
2School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, AZ USA.
Indian J Microbiol. 2018 Mar;58(1):114-117. doi: 10.1007/s12088-017-0694-9. Epub 2017 Dec 16.
Acute hepatopancreatic necrosis disease (AHPND) caused by has been one of the most problematic diseases in marine shrimp aquaculture throughout Southeast Asia and Latin America. To evaluate the effectiveness of a bacteriophage (phage) treatment for AHPND, a series of bioassays were carried out in a marine shrimp () model using an AHPND- strain that is highly pathogenic to shrimp. We monitored the mortality and histopathological changes during phage treatment. Shrimps treated with phage prophylaxis and phage therapy displayed significant protection from AHPND and survived a lethal bacterial challenge.
由[具体病原体]引起的急性肝胰腺坏死病（AHPND）一直是东南亚和拉丁美洲整个海水虾养殖中最具问题的疾病之一。为了评估噬菌体治疗AHPND的有效性，在一个海水虾（[虾的品种]）模型中，使用对虾具有高致病性的AHPND-[菌株名称]菌株进行了一系列生物测定。我们监测了噬菌体治疗期间的死亡率和组织病理学变化。接受噬菌体预防和噬菌体治疗的虾对AHPND表现出显著的保护作用，并在致命的细菌攻击中存活下来。
