Department of Pharmaceutical Botany, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania.
Department of Pharmaceutical Technology and Biopharmaceutics, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400010 Cluj-Napoca, Romania.
Molecules. 2018 Feb 13;23(2):409. doi: 10.3390/molecules23020409.
(L.) Gaertn. and (L.) Moench. are two species of the Asteraceae family, known in Romanian traditional medicine for their diuretic, choleretic, and anti-inflammatory properties. The aim of the present study was to evaluate the phenolic and sterolic composition of flowers from the two species and to assess their antioxidant, antibacterial and antifungal properties. LC-MS analyses were performed on methanolic, ethanolic and 70% ethanolic extracts, before and after acid hydrolysis, and revealed high amounts of polyphenols. Chlorogenic acid was found as the main compound for the flowers of (502.70 ± 25.11 mg/100 g d.w.), while quercitrin was dominant in (424.28 ± 21.21 mg/100 g d.w.) in 70% / ethanolic extracts before hydrolysis. Antioxidant capacity assays showed an important antioxidant potential, which can be correlated with the determined polyphenolic compounds, showing the 70% / ethanolic extracts of the two species as being the most effective antioxidant samples for the DPPH assay. Antibacterial and antifungal assays confirm a modest biological potential for the same extract of both species. Results obtained in the present study bring important data and offer scientific evidence on the chemical composition and on the biological activities of the flowers belonging to the two species.
(L.) Gaertn. 和 (L.) Moench. 是菊科的两个物种，在罗马尼亚传统医学中因其利尿、利胆和抗炎特性而闻名。本研究的目的是评估两种植物花的酚类和甾醇类成分，并评估其抗氧化、抗菌和抗真菌特性。通过 LC-MS 分析甲醇、乙醇和 70%乙醇提取物，在酸水解前后，发现了大量的多酚。绿原酸被发现是 (502.70 ± 25.11 mg/100 g d.w.) 花中的主要化合物，而槲皮素在水解前 70%/乙醇提取物中是 (424.28 ± 21.21 mg/100 g d.w.) 的主要化合物。抗氧化能力测定表明具有重要的抗氧化潜力，这与测定的多酚化合物相关，表明两种植物的 70%/乙醇提取物是 DPPH 测定中最有效的抗氧化样品。抗菌和抗真菌试验证实了同一提取物具有适度的生物潜力。本研究的结果提供了关于两种植物花的化学成分和生物活性的重要数据和科学证据。
