R. M. Alden Research Lab, Culver City, California, USA
David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Antimicrob Agents Chemother. 2018 Mar 27;62(4). doi: 10.1128/AAC.02551-17. Print 2018 Apr.
Omadacycline was tested against 125 isolates recovered from infected cat and dog bites in humans. Its activity was similar to that of other compounds in the tetracycline class, and it was active against strains exhibiting tetracycline resistance. Against anaerobic isolates, resistance to tetracyclines was more prominent and omadacycline was the most active of the group. All isolates had omadacycline MICs of <1 μg/ml, with the exception of , which showed reduced susceptibility to the entire tetracycline group.
奥马环素对从感染猫和狗咬伤的人类中分离的 125 株分离株进行了测试。其活性与四环素类中的其他化合物相似，并且对表现出四环素耐药性的菌株具有活性。对于厌氧分离株，对四环素的耐药性更为突出，奥马环素是该组中最活跃的。所有分离株的奥马环素 MIC 值均<1μg/ml，除 株外，该株对整个四环素类药物均表现出较低的敏感性。
