环丙沙星和头孢曲松在大肠杆菌所致实验性关节炎中的疗效比较
Comparative efficacy of ciprofloxacin and ceftriaxone in experimental arthritis caused by Escherichia coli.
作者信息
Bayer A S, Norman D C, Blomquist I K
出版信息
Antimicrob Agents Chemother. 1986 Jul;30(1):184-6. doi: 10.1128/AAC.30.1.184.
Abstract
Ciprofloxacin was compared with ceftriaxone in a rabbit model of septic arthritis caused by Escherichia coli. Both agents significantly reduced mean E. coli counts in septic joint fluid (P less than 0.0005 versus untreated controls) and also within infected synovial tissue (P less than 0.01 versus controls). Ciprofloxacin regimens caused a higher frequency (P less than 0.05) of synovial tissue sterilization (53%) than did ceftriaxone (25%).
摘要
在由大肠杆菌引起的脓毒性关节炎兔模型中，将环丙沙星与头孢曲松进行了比较。两种药物均显著降低了脓毒性关节液中的平均大肠杆菌计数（与未治疗的对照组相比，P<0.0005），并且在感染的滑膜组织中也有显著降低（与对照组相比，P<0.01）。与头孢曲松（25%）相比，环丙沙星治疗方案导致滑膜组织杀菌的频率更高（P<0.05）（53%）。
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