环丙沙星纸片药敏试验：5微克纸片的解释性抑菌圈大小标准
Ciprofloxacin disk susceptibility tests: interpretive zone size standards for 5-microgram disks.
作者信息
Barry A L, Fass R J, Anhalt J P, Neu H C, Thornsberry C, Tilton R C, Painter B G, Washington J A
出版信息
J Clin Microbiol. 1985 Jun;21(6):880-3. doi: 10.1128/jcm.21.6.880-883.1985.
Abstract
Evaluations of 5-microgram ciprofloxacin disk diffusion susceptibility tests were performed independently by seven different investigators. The results of the separate tests were combined to increase the number of resistant strains in the challenge set of microorganisms. Based on data with 2,652 isolates, the following interpretive breakpoints are tentatively proposed for use in ongoing clinical trials of ciprofloxacin: less than or equal to 15 mm, resistant (MIC greater than 2.0 micrograms/ml); 16 to 20 mm, intermediate (1.0 less than MIC less than or equal to 2.0 micrograms/ml); and greater than or equal to 21 mm, susceptible (MIC less than or equal to 1.0 micrograms/ml). Disk tests with Streptococcus spp. and with Pseudomonas maltophilia were not reliable; other microorganisms were accurately categorized by the disk diffusion test.
摘要
七名不同的研究人员分别独立进行了5微克环丙沙星纸片扩散药敏试验评估。将各个试验的结果合并，以增加微生物挑战集中耐药菌株的数量。基于2652株分离菌的数据，初步提出以下解释性断点，用于环丙沙星正在进行的临床试验：小于或等于15毫米，耐药（最低抑菌浓度大于2.0微克/毫升）；16至20毫米，中介（1.0＜最低抑菌浓度≤2.0微克/毫升）；大于或等于21毫米，敏感（最低抑菌浓度≤1.0微克/毫升）。用链球菌属和嗜麦芽窄食单胞菌进行的纸片试验不可靠；其他微生物通过纸片扩散试验能准确分类。
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