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相似文献

1
Expression of the v-src or v-fps oncogene increases fructose 2,6-bisphosphate in chick-embryo fibroblasts. Novel mechanism for the stimulation of glycolysis by retroviruses.v-src 或 v-fps 癌基因的表达可增加鸡胚成纤维细胞中果糖 2,6-二磷酸的含量。逆转录病毒刺激糖酵解的新机制。
Biochem J. 1986 Jun 1;236(2):595-9. doi: 10.1042/bj2360595.
2
Phorbol 12-myristate 13-acetate and insulin increase the concentration of fructose 2,6-bisphosphate and stimulate glycolysis in chicken embryo fibroblasts.佛波醇12 -肉豆蔻酸酯13 -乙酸酯和胰岛素可增加鸡胚成纤维细胞中果糖2,6 -二磷酸的浓度并刺激糖酵解。
Proc Natl Acad Sci U S A. 1985 Oct;82(19):6440-4. doi: 10.1073/pnas.82.19.6440.
3
Effect of glutamine on fructose 2,6-bisphosphate and on glucose metabolism in HeLa cells and in chick-embryo fibroblasts.谷氨酰胺对HeLa细胞和鸡胚成纤维细胞中果糖2,6 -二磷酸及葡萄糖代谢的影响。
Biochem J. 1985 Dec 1;232(2):521-7. doi: 10.1042/bj2320521.
4
Activation of 6-phosphofructo-2-kinase by pp60v-src is an indirect effect.pp60v-src对6-磷酸果糖-2-激酶的激活是一种间接效应。
Biochem J. 1992 Jul 15;285 ( Pt 2)(Pt 2):413-7. doi: 10.1042/bj2850413.
5
Fructose 2,6-bisphosphate and insulin stimulation of glycolysis in 3T3-L1 adipocytes.果糖-2,6-二磷酸与胰岛素对3T3-L1脂肪细胞糖酵解的刺激作用。
Int J Biochem. 1989;21(12):1359-63. doi: 10.1016/0020-711x(89)90156-0.
6
Fructose 2,6-bisphosphate and the control of glycolysis by growth factors, tumor promoters and oncogenes.果糖-2,6-二磷酸与生长因子、肿瘤启动子和癌基因对糖酵解的调控
Adv Enzyme Regul. 1993;33:97-110. doi: 10.1016/0065-2571(93)90011-2.
7
Regulation of fructose 2,6-bisphosphate metabolism in human fibroblasts.
Biochim Biophys Acta. 1986 Jun 16;887(1):23-8. doi: 10.1016/0167-4889(86)90117-5.
8
Increase of the glycolytic rate in human resting fibroblasts following serum stimulation. The possible role of the fructose-2,6-bisphosphate.
FEBS Lett. 1983 Aug 8;159(1-2):39-42. doi: 10.1016/0014-5793(83)80412-8.
9
[Fructose-2,6-diphosphate and glycolysis of tumor cells].[果糖-2,6-二磷酸与肿瘤细胞的糖酵解]
Bull Mem Acad R Med Belg. 1989;144(11):570-7; discussion 578-9.
10
Adenylate cyclase stimulating agents and mitogens raise fructose 2,6-bisphosphate levels in human fibroblasts. Evidence for a dual control of the metabolite.腺苷酸环化酶刺激剂和促细胞分裂剂可提高人成纤维细胞中果糖2,6 -二磷酸的水平。该代谢物存在双重调控的证据。
FEBS Lett. 1987 Sep 28;222(1):27-31. doi: 10.1016/0014-5793(87)80185-0.

引用本文的文献

1
Lactate mediated metabolic crosstalk between cancer and immune cells and its therapeutic implications.乳酸介导的癌症与免疫细胞之间的代谢串扰及其治疗意义。
Front Oncol. 2023 May 10;13:1175532. doi: 10.3389/fonc.2023.1175532. eCollection 2023.
2
Src: coordinating metabolism in cancer.Src：协调癌症中的代谢。
Oncogene. 2022 Nov;41(45):4917-4928. doi: 10.1038/s41388-022-02487-4. Epub 2022 Oct 10.
3
Oncogenic virus-induced aerobic glycolysis and tumorigenesis.致癌病毒诱导的有氧糖酵解与肿瘤发生。
J Cancer. 2018 Sep 8;9(20):3699-3706. doi: 10.7150/jca.27279. eCollection 2018.
4
Src drives the Warburg effect and therapy resistance by inactivating pyruvate dehydrogenase through tyrosine-289 phosphorylation.Src通过酪氨酸289磷酸化使丙酮酸脱氢酶失活，从而驱动瓦伯格效应和治疗抗性。
Oncotarget. 2016 May 3;7(18):25113-24. doi: 10.18632/oncotarget.7159.
5
Targeting the metabolic microenvironment of tumors.靶向肿瘤的代谢微环境。
Adv Pharmacol. 2012;65:63-107. doi: 10.1016/B978-0-12-397927-8.00004-X.
6
Oncogenic viruses and tumor glucose metabolism: like kids in a candy store.致癌病毒与肿瘤葡萄糖代谢：就像孩子在糖果店里。
Mol Cancer Ther. 2012 Jan;11(1):14-23. doi: 10.1158/1535-7163.MCT-11-0517.
7
The molecular determinants of de novo nucleotide biosynthesis in cancer cells.癌细胞中从头核苷酸生物合成的分子决定因素。
Curr Opin Genet Dev. 2009 Feb;19(1):32-7. doi: 10.1016/j.gde.2009.01.002. Epub 2009 Feb 5.
8
Mayaro virus infection alters glucose metabolism in cultured cells through activation of the enzyme 6-phosphofructo 1-kinase.马亚罗病毒感染通过激活6-磷酸果糖-1-激酶改变培养细胞中的葡萄糖代谢。
Mol Cell Biochem. 2004 Nov;266(1-2):191-8. doi: 10.1023/b:mcbi.0000049154.17866.00.
9
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: head-to-head with a bifunctional enzyme that controls glycolysis.6-磷酸果糖-2-激酶/果糖-2,6-二磷酸酶：与一种控制糖酵解的双功能酶呈头对头结构
Biochem J. 2004 Aug 1;381(Pt 3):561-79. doi: 10.1042/BJ20040752.
10
Effects of overexpression of the liver subunit of 6-phosphofructo-1-kinase on the metabolism of a cultured mammalian cell line.6-磷酸果糖-1-激酶肝脏亚基过表达对一种培养的哺乳动物细胞系代谢的影响。
Biochem J. 2000 Dec 15;352 Pt 3(Pt 3):921-7.

本文引用的文献

1
Relationship between increased aerobic glycolysis and DNA synthesis initiation studied using glycolytic mutant fibroblasts.利用糖酵解突变成纤维细胞研究有氧糖酵解增加与DNA合成起始之间的关系。
Nature. 1980 Oct 2;287(5781):445-7. doi: 10.1038/287445a0.
2
Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.肿瘤促进剂佛波酯对钙激活的、磷脂依赖性蛋白激酶的直接激活作用。
J Biol Chem. 1982 Jul 10;257(13):7847-51.
3
Fructose 2,6-bisphosphate, the probably structure of the glucose- and glucagon-sensitive stimulator of phosphofructokinase.果糖2,6-二磷酸，可能是磷酸果糖激酶的葡萄糖和胰高血糖素敏感刺激物的结构。
Biochem J. 1980 Dec 15;192(3):897-901. doi: 10.1042/bj1920897.
4
Serine- and threonine-specific protein kinase activities of purified gag-mil and gag-raf proteins.纯化的gag-mil和gag-raf蛋白的丝氨酸和苏氨酸特异性蛋白激酶活性。
Nature. 1984;312(5994):558-61. doi: 10.1038/312558a0.
5
Evidence that the Rous sarcoma virus transforming gene product phosphorylates phosphatidylinositol and diacylglycerol.劳氏肉瘤病毒转化基因产物使磷脂酰肌醇和二酰基甘油磷酸化的证据。
Proc Natl Acad Sci U S A. 1984 Apr;81(7):2117-21. doi: 10.1073/pnas.81.7.2117.
6
Molecular events leading to enhanced glucose transport in Rous sarcoma virus-transformed cells.导致劳氏肉瘤病毒转化细胞中葡萄糖转运增强的分子事件。
Fed Proc. 1984 May 15;43(8):2246-50.
7
The role of protein kinase C in cell surface signal transduction and tumour promotion.蛋白激酶C在细胞表面信号转导及肿瘤促进中的作用。
Nature. 1984;308(5961):693-8. doi: 10.1038/308693a0.
8
Increase of the glycolytic rate in human resting fibroblasts following serum stimulation. The possible role of the fructose-2,6-bisphosphate.
FEBS Lett. 1983 Aug 8;159(1-2):39-42. doi: 10.1016/0014-5793(83)80412-8.
9
The proteins of oncogenes.致癌基因的蛋白质
Sci Am. 1984 Aug;251(2):70-9. doi: 10.1038/scientificamerican0884-70.
10
Three glycolytic enzymes are phosphorylated at tyrosine in cells transformed by Rous sarcoma virus.在被劳氏肉瘤病毒转化的细胞中，三种糖酵解酶在酪氨酸位点发生磷酸化。
Nature. 1983;302(5905):218-23. doi: 10.1038/302218a0.

v-src 或 v-fps 癌基因的表达可增加鸡胚成纤维细胞中果糖 2,6-二磷酸的含量。逆转录病毒刺激糖酵解的新机制。

Expression of the v-src or v-fps oncogene increases fructose 2,6-bisphosphate in chick-embryo fibroblasts. Novel mechanism for the stimulation of glycolysis by retroviruses.

作者信息

Bosca L, Mojena M, Ghysdael J, Rousseau G G, Hue L

出版信息

Biochem J. 1986 Jun 1;236(2):595-9. doi: 10.1042/bj2360595.

DOI:10.1042/bj2360595
PMID:2944513
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1146881/
Abstract

The concentration of fructose 2,6-bisphosphate and the activity of 6-phosphofructo-2-kinase are increased after infection of chick-embryo fibroblasts with the Rous sarcoma virus, or with a temperature-sensitive mutant of this virus at the permissive, but not at the non-permissive, temperature. This is observed after transformation by retroviruses carrying either the v-src or v-fps, but not the v-mil and/or v-myc, oncogenes. Comparison of the effects of the Rous sarcoma virus with those of phorbol myristate acetate on fructose 2,6-bisphosphate suggests that both result from the stimulation of a step which is rate-limiting for 6-phosphofructo-2-kinase activation and which is also controlled by protein kinase C.

摘要

用劳氏肉瘤病毒或该病毒的温度敏感突变体感染鸡胚成纤维细胞后，在允许温度而非非允许温度下，果糖2,6 - 二磷酸的浓度和6 - 磷酸果糖 - 2 - 激酶的活性会增加。在用携带v-src或v-fps而非v-mil和/或v-myc癌基因的逆转录病毒转化后可观察到这种情况。将劳氏肉瘤病毒的作用与佛波酯对果糖2,6 - 二磷酸的作用进行比较表明，两者都是由对6 - 磷酸果糖 - 2 - 激酶激活起限速作用且也受蛋白激酶C控制的一个步骤的刺激所导致的。