v-src 或 v-fps 癌基因的表达可增加鸡胚成纤维细胞中果糖 2,6-二磷酸的含量。逆转录病毒刺激糖酵解的新机制。
Expression of the v-src or v-fps oncogene increases fructose 2,6-bisphosphate in chick-embryo fibroblasts. Novel mechanism for the stimulation of glycolysis by retroviruses.
作者信息
Bosca L, Mojena M, Ghysdael J, Rousseau G G, Hue L
出版信息
Biochem J. 1986 Jun 1;236(2):595-9. doi: 10.1042/bj2360595.
Abstract
The concentration of fructose 2,6-bisphosphate and the activity of 6-phosphofructo-2-kinase are increased after infection of chick-embryo fibroblasts with the Rous sarcoma virus, or with a temperature-sensitive mutant of this virus at the permissive, but not at the non-permissive, temperature. This is observed after transformation by retroviruses carrying either the v-src or v-fps, but not the v-mil and/or v-myc, oncogenes. Comparison of the effects of the Rous sarcoma virus with those of phorbol myristate acetate on fructose 2,6-bisphosphate suggests that both result from the stimulation of a step which is rate-limiting for 6-phosphofructo-2-kinase activation and which is also controlled by protein kinase C.
摘要
用劳氏肉瘤病毒或该病毒的温度敏感突变体感染鸡胚成纤维细胞后，在允许温度而非非允许温度下，果糖2,6 - 二磷酸的浓度和6 - 磷酸果糖 - 2 - 激酶的活性会增加。在用携带v-src或v-fps而非v-mil和/或v-myc癌基因的逆转录病毒转化后可观察到这种情况。将劳氏肉瘤病毒的作用与佛波酯对果糖2,6 - 二磷酸的作用进行比较表明，两者都是由对6 - 磷酸果糖 - 2 - 激酶激活起限速作用且也受蛋白激酶C控制的一个步骤的刺激所导致的。
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本文引用的文献
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Relationship between increased aerobic glycolysis and DNA synthesis initiation studied using glycolytic mutant fibroblasts.利用糖酵解突变成纤维细胞研究有氧糖酵解增加与DNA合成起始之间的关系。
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