Liebig-Hörl G, Puchner C, Gerken M, Klinkhammer-Schalke M, Fürst A
Klinik für Allgemein‑, Viszeral‑, Thoraxchirurgie, Adipositasmedizin, Caritas-Krankenhaus St. Josef, Landshuterstr. 65, 93053, Regensburg, Deutschland.
Tumorzentrum Regensburg, Regensburg, Deutschland.
Chirurg. 2018 May;89(5):358-364. doi: 10.1007/s00104-018-0603-8.
A common consensus for the definition for early rectal cancer does not exist. This item is used in cases of histological findings including pTis, pT1 or pT2 tumors. The term early rectal cancer is not mentioned in the German S3 guidelines on colorectal cancer. The pTis tumors are located at the mucosa level of the intestinal wall and they have nearly no tendency to develop metastases but pT2 tumors have a high risk of local metastases; therefore, the term early rectal cancer is not adequate for pT2 tumors.
This focus of this article is exclusively on pT1 rectal cancer. Following the histological definition, pT1 tumors of the rectum are located at the level of the mucosa and submucosa of the intestinal wall.
With respect to the nature of the tumor (e.g. size, grading, invasion of lymphatic and/or blood vessels, Kikuchi classification) local methods (endoscopic procedure, surgical techniques) or radical resections are recommended. Tumor budding is of increasing interest and importance. Depending on the severity of the tumor budding classification (bd1-bd3) there is an association with a more frequent occurrence of lymph node metastases and should therefore be taken into consideration in treatment decisions in the future.
目前对于早期直肠癌的定义尚无普遍共识。该术语用于组织学检查结果为包括pTis、pT1或pT2肿瘤的病例。德国结直肠癌S3指南中未提及早期直肠癌这一术语。pTis肿瘤位于肠壁黏膜层,几乎没有发生转移的倾向,但pT2肿瘤有较高的局部转移风险;因此,早期直肠癌这一术语并不适用于pT2肿瘤。
本文重点仅关注pT1期直肠癌。根据组织学定义,直肠的pT1肿瘤位于肠壁黏膜和黏膜下层。
就肿瘤的性质(如大小、分级、淋巴管和/或血管侵犯、菊池分类)而言,建议采用局部方法(内镜手术、外科技术)或根治性切除术。肿瘤芽生越来越受到关注且具有重要意义。根据肿瘤芽生分级(bd1-bd3)的严重程度,其与淋巴结转移的更频繁发生有关,因此在未来的治疗决策中应予以考虑。