a Snyder Institute for Chronic Diseases , University of Calgary , Calgary , AB , Canada.
Platelets. 2018 Sep;29(6):549-555. doi: 10.1080/09537104.2018.1428739. Epub 2018 Feb 15.
Platelets patrol the vasculature and adhere at sites of vascular damage after trauma to limit blood loss. In recent years, however, it has become clear that platelets also contribute to pathophysiologic processes such as thrombosis, atherosclerosis, stroke, sepsis and many more. An exciting new role for them is in non-classical hemostasis to prevent bleeding in the inflamed vasculature. Recent studies suggest that GPVI, CLEC-2, integrin αIIbβ3 (GPIIb/IIIa), and the content of platelet α- and dense granules are important players in this process. This review summarizes the current knowledge about how platelets prevent vascular integrity during inflammation in the skin, lung, and the ischemic brain and their organ-specific role.
血小板在血管中巡逻，并在创伤后黏附在血管损伤部位，以限制失血。然而，近年来，人们已经清楚地认识到，血小板也会导致病理生理过程，如血栓形成、动脉粥样硬化、中风、败血症等。它们的一个令人兴奋的新角色是在非经典止血中，以防止炎症血管中的出血。最近的研究表明，GPVI、CLEC-2、整合素αIIbβ3（GPIIb/IIIa）和血小板α-和致密颗粒的内容物是这个过程中的重要参与者。这篇综述总结了目前关于血小板如何在皮肤、肺和缺血性大脑的炎症过程中维持血管完整性的知识，以及它们在特定器官中的作用。
