Angoorani Pooneh, Heshmat Ramin, Ejtahed Hanieh-Sadat, Motlagh Mohammad Esmaeil, Ziaodini Hasan, Taheri Majzoubeh, Aminaee Tahereh, Goodarzi Azam, Qorbani Mostafa, Kelishadi Roya
Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Eat Weight Disord. 2018 Dec;23(6):877-883. doi: 10.1007/s40519-018-0488-z. Epub 2018 Feb 16.
The purpose of this study was to determine the cut-off values of triglycerides and glucose (TyG) index as one of the indirect indices for metabolic syndrome (MetS) in a pediatric population.
This national study was conducted in 2015 on 14400 students, aged 7-18 years. They were selected by random cluster sampling from 30 provinces of our country during the fifth survey of a national school-based surveillance program. MetS was defined based on the Adult Treatment Panel III (ATP III) criteria modified for the pediatric age group. The cut-off values of TyG index for MetS were obtained using the receiver operation characteristic (ROC) curve analysis by gender and age groups.
Totally, 3843 students (52.3% boys) with mean (SD) age of 12.45 (3.04) years were assessed. The area under the ROC curve of TyG index for MetS was 0.83 in total participants. According to the ATP III criteria the cut-off values of the TyG index were 8.33 (8.21-8.45) in total students, 8.47 (8.36-8.58) in boys, and 8.33 (8.18-8.48) in girls. In the 7-12 and 13-18 years' age groups, these values were 8.47 (8.32-8.63) and 8.34 (8.22-8.45) in total, 8.39 (8.26-8.52) and 8.47 (8.33-8.61) in boys, 8.33 (8.11-8.55) and 8.35 (8.22-8.47) in girls, respectively.
The findings of this study can be clinically helpful for screening MetS in children and adolescents but the effectiveness of these criteria needs to be evaluated by further longitudinal surveys.
Level V, cross-sectional descriptive study (National surveillance study).
本研究旨在确定甘油三酯和血糖（TyG）指数作为儿童代谢综合征（MetS）间接指标之一的临界值。
这项全国性研究于2015年对14400名7至18岁的学生进行。他们是在全国学校监测项目的第五次调查期间，从我国30个省份通过随机整群抽样选取的。MetS根据针对儿童年龄组修改的成人治疗小组第三次报告（ATP III）标准进行定义。通过性别和年龄组，使用受试者工作特征（ROC）曲线分析获得MetS的TyG指数临界值。
总共评估了3843名学生（52.3%为男孩），平均（标准差）年龄为12.45（3.04）岁。全体参与者中，MetS的TyG指数ROC曲线下面积为0.83。根据ATP III标准，全体学生的TyG指数临界值为8.33（8.21 - 8.45），男孩为8.47（8.36 - 8.58），女孩为8.33（8.18 - 8.48）。在7至12岁和13至18岁年龄组中，全体的这些值分别为8.47（8.32 - 8.63）和8.34（8.22 - 8.45），男孩为8.39（8.26 - 8.52）和8.47（8.33 - 8.61），女孩为8.33（8.11 - 8.55）和8.35（8.22 - 8.47）。
本研究结果在临床上有助于筛查儿童和青少年的MetS，但这些标准的有效性需要通过进一步的纵向调查进行评估。
V级，横断面描述性研究（全国监测研究）。
