University of Chinese Academy of Sciences , Beijing 100049 , P. R. China.
ACS Appl Mater Interfaces. 2018 Mar 14;10(10):8436-8442. doi: 10.1021/acsami.7b17219. Epub 2018 Mar 1.
Nowadays, two-dimensional (2D) materials have attracted extensive attention as cancer drug delivery platforms owing to their unparalleled physicochemical properties and superior specific surface area. Graphdiyne (GDY) is a novel 2D carbon material. Compared with graphene, GDY not only has benzene rings composed of sp-hybridized carbon atoms but also has acetylene units composed of sp-hybridized carbon atoms; therefore, it possesses multiple conjugated electronic structures. Herein, we used doxorubicin (DOX) as a model drug to develop a GDY nanosheet-based drug delivery platform for a photothermal/chemotherapy combination in living mice. With a high photothermal conversion ability and drug loading efficiency, GDY/DOX under 808 nm laser irradiation showed a much higher cancer inhibition rate compared with solo therapy both in vitro and in vivo. Furthermore, GDY exhibited great biocompatibility and no obvious side effects, as shown by histopathological examination and serum biochemical analysis. For the first time, our work demonstrated a successful example of GDY for efficient photothermal/chemotherapy and suggests both safety and great promise for GDY in cancer treatment.
如今，二维（2D）材料因其无与伦比的物理化学性质和优越的比表面积而作为癌症药物输送平台引起了广泛关注。二维碳材料石墨炔（GDY）是一种新型的 2D 碳材料。与石墨烯相比，GDY 不仅具有由 sp 杂化碳原子组成的苯环，而且具有由 sp 杂化碳原子组成的乙炔单元，因此具有多种共轭电子结构。在这里，我们使用阿霉素（DOX）作为模型药物，开发了基于 GDY 纳米片的药物输送平台，用于活体小鼠的光热/化疗联合治疗。具有高的光热转换能力和载药效率，GDY/DOX 在 808nm 激光照射下，无论是在体外还是体内，其癌症抑制率均明显高于单独治疗。此外，组织病理学检查和血清生化分析表明，GDY 表现出良好的生物相容性，没有明显的副作用。这是首次成功将 GDY 用于高效光热/化疗的例子，表明 GDY 在癌症治疗中具有安全性和巨大的应用前景。
