固态纳米孔

Yuan Zhishan, Wang Chengyong, Yi Xin, Ni Zhonghua, Chen Yunfei, Li Tie

School of Electromechanical Engineering, Guangdong University of Technology, Guangzhou, 510006, China.

School of Medicine, South China University of Technology, Guangzhou, 510006, China.

Nanoscale Res Lett. 2018 Feb 20;13(1):56. doi: 10.1186/s11671-018-2463-z.

Solid-state nanopore has captured the attention of many researchers due to its characteristic of nanoscale. Now, different fabrication methods have been reported, which can be summarized into two broad categories: "top-down" etching technology and "bottom-up" shrinkage technology. Ion track etching method, mask etching method chemical solution etching method, and high-energy particle etching and shrinkage method are exhibited in this report. Besides, we also discussed applications of solid-state nanopore fabrication technology in DNA sequencing, protein detection, and energy conversion.

固态纳米孔因其纳米尺度特性而吸引了众多研究人员的关注。目前，已有多种不同的制备方法被报道，可大致分为两大类：“自上而下”蚀刻技术和“自下而上”收缩技术。本报告展示了离子径迹蚀刻法、掩膜蚀刻法、化学溶液蚀刻法以及高能粒子蚀刻与收缩法。此外，我们还讨论了固态纳米孔制备技术在DNA测序、蛋白质检测和能量转换方面的应用。