Lai Yuxuan, Wang Lijun, Liu Yuan, Yang Gaojian, Tang Congli, Deng Yan, Li Song
J Biomed Nanotechnol. 2018 Jan 1;14(1):44-65. doi: 10.1166/jbn.2018.2505.
Nanomaterials have been widely used to immobilize biomolecules, amplify the signals and concentrate the analytes for detection with good properties including large surface area, good adsorption capacity and high surface activity. In recent years, nanomaterials such as carbon nanomaterials, noble metal nanomaterials, polymers, are widely applied to research and develop immunosensors with high sensitivity and selectivity, which monitor the antigen-antibody reaction for the detection of tumor markers. This review provides an introduction of immunosensors and focuses on the design of electrochemical (EC) immunosensors, electrochemical luminscence (ECL) immunosensors and photoelectrochemical (PEC) immunosensors based on nanomaterials in nearly three years.
纳米材料已被广泛用于固定生物分子、放大信号并浓缩分析物，以实现具有良好性能的检测，这些性能包括大表面积、良好的吸附能力和高表面活性。近年来，碳纳米材料、贵金属纳米材料、聚合物等纳米材料被广泛应用于研发具有高灵敏度和选择性的免疫传感器，这些传感器监测抗原-抗体反应以检测肿瘤标志物。本文综述介绍了免疫传感器，并重点关注近三年基于纳米材料的电化学（EC）免疫传感器、电化学发光（ECL）免疫传感器和光电化学（PEC）免疫传感器的设计。
