Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Shushan District, Hefei, 230032, Anhui, People's Republic of China.
Department of Head and Neck, Breast Surgery, Anhui Provincial Cancer Hospital, No. 107 East Lake Road, Hefei, 230032, Anhui, People's Republic of China.
J Endocrinol Invest. 2018 Oct;41(10):1199-1210. doi: 10.1007/s40618-018-0853-9. Epub 2018 Feb 20.
Although vitamin D is reportedly associated with various cancers, the association between vitamin D and thyroid cancer is indefinite. We aimed to investigate whether this association applies to thyroid cancer (TC).
A total of 276 Chinese Han people were recruited in a current matched case-control study. Multivariable conditional logistic regression was computed to estimate the association between plasma 25(OH)D and papillary thyroid cancer (PTC). In addition, we searched relevant studies in PubMed and Web of Science databases before December 2017 to conduct a meta-analysis.
In our case-control study, plasma 25(OH)D concentration was inversely associated with PTC risk (highest tertile vs lowest tertile: adjusted OR = 0.25; 95% CI 0.10, 0.61; P = 0.003). This association was independent of body mass index and physical activity (all adjusted P > 0.05). A total of 11 studies were included in the meta-analysis, among which ten studies have been published and one was our case-control study. Compared with 25(OH)D non-deficient group, the pooled OR of TC was 1.42 (95% CI 1.17, 1.73) in the deficient group. Similarly, blood 25(OH)D levels in patients with TC were tend to be lower than those in the controls (SMD = - 0.20, 95% CI - 0.36, - 0.03).
A high level of circulating 25(OH)D was associated with a decreased TC risk. This association has important significance in public health and should, therefore, be further studied.
虽然维生素 D 与各种癌症有关，但维生素 D 与甲状腺癌之间的关系尚未确定。本研究旨在探讨这种关系是否适用于甲状腺癌（TC）。
采用病例对照研究，共纳入 276 名汉族人。采用多变量条件 logistic 回归估计血浆 25（OH）D 与甲状腺乳头状癌（PTC）的相关性。此外，我们还在 PubMed 和 Web of Science 数据库中检索了截至 2017 年 12 月的相关研究，进行了荟萃分析。
在病例对照研究中，血浆 25（OH）D 浓度与 PTC 风险呈负相关（最高三分位组与最低三分位组相比：调整后的 OR=0.25；95%CI：0.10，0.61；P=0.003）。这种关联与体重指数和体力活动无关（所有调整后的 P>0.05）。荟萃分析共纳入 11 项研究，其中 10 项研究已发表，1 项为我们的病例对照研究。与 25（OH）D 不缺乏组相比，25（OH）D 缺乏组 TC 的合并 OR 为 1.42（95%CI：1.17，1.73）。同样，TC 患者的血 25（OH）D 水平也倾向于低于对照组（SMD=-0.20，95%CI：-0.36，-0.03）。
高水平的循环 25（OH）D 与 TC 风险降低相关。这种关联在公共卫生方面具有重要意义，因此应进一步研究。
