人类记忆 T 细胞：生成、区室化和动态平衡。
Human memory T cells: generation, compartmentalization and homeostasis.
机构信息
1] Columbia Center for Translational Immunology and Department of Microbiology and Immunology, Columbia University Medical Center, 650 West 168th Street, BB1501, New York, New York 10032, USA. [2] Department of Surgery, Columbia University Medical Center, 650 West 168th Street, BB1501, New York 10032, USA.
Columbia Center for Translational Immunology and Department of Microbiology and Immunology, Columbia University Medical Center, 650 West 168th Street, BB1501, New York, New York 10032, USA.
出版信息
Nat Rev Immunol. 2014 Jan;14(1):24-35. doi: 10.1038/nri3567. Epub 2013 Dec 13.
Memory T cells constitute the most abundant lymphocyte population in the body for the majority of a person's lifetime; however, our understanding of memory T cell generation, function and maintenance mainly derives from mouse studies, which cannot recapitulate the exposure to multiple pathogens that occurs over many decades in humans. In this Review, we discuss studies focused on human memory T cells that reveal key properties of these cells, including subset heterogeneity and diverse tissue residence in multiple mucosal and lymphoid tissue sites. We also review how the function and the adaptability of human memory T cells depend on spatial and temporal compartmentalization.
记忆 T 细胞在人体一生中的大部分时间构成了最丰富的淋巴细胞群体；然而，我们对记忆 T 细胞的生成、功能和维持的理解主要来自于小鼠研究，这些研究无法重现人类在几十年中多次接触多种病原体的情况。在这篇综述中，我们讨论了专注于人类记忆 T 细胞的研究，这些研究揭示了这些细胞的关键特性，包括亚群异质性和在多个黏膜和淋巴组织部位的不同组织驻留。我们还回顾了人类记忆 T 细胞的功能和适应性如何取决于空间和时间的分区。
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