Lunacek Libor, Gärtner Marcel, Krhut Jan, Mika David, Sykora Radek, Zvara Peter
Department of Urology, University Hospital, 17. listopadu 1790, 708 52, Ostrava, Poruba, Czech Republic.
Department of Surgical Studies, Ostrava University, Ostrava, Czech Republic.
Int Urogynecol J. 2018 Oct;29(10):1523-1527. doi: 10.1007/s00192-018-3571-0. Epub 2018 Feb 24.
The objective was to evaluate the intra-individual variability of uroflowmetry (UFM) in healthy control subjects and women suffering from stress, urge, and mixed urinary incontinence.
A total of 35 healthy controls (group A) and 105 women suffering from urinary incontinence were enrolled in the study. Thirty-five women suffered from stress urinary incontinence (group B), 35 women suffered from mixed urinary incontinence (group C), and 35 women with overactive bladder both dry and wet (group D). All participants were asked to perform UFM measurement three times. The following parameters were analyzed: voided volume (VV), peak flow (Q), average flow (Q), volume-corrected peak flow cQ (cQ = Q/√ VV), volume-corrected average flow (cQ = Q/√ VV), and postvoid residual volume (PVR). Statistical analysis was performed using the analysis of variance on repeated measurements. Relative error was calculated using variation coefficients reported as a percentage of the average. All descriptive characteristics were reported as means ± standard deviation (SD). p values ≤0.05 were considered statistically significant.
No statistically significant intra-individual difference in any of the recorded parameters was identified among the three UFM recordings in groups A, C, and D. The intra-individual variability of the following parameters reached statistical significance in patients suffering from stress urinary incontinence (group B): Q (p = 0.0016), Q (p = 0.0005), and cQ (p = 0.0389). A significant difference was only observed in comparison between the first and second consecutive recordings.
This study provides evidence supporting the high yield and good intra-individual reproducibility of UFM.
目的是评估健康对照受试者以及患有压力性、急迫性和混合性尿失禁的女性尿流率测定（UFM）的个体内变异性。
本研究共纳入35名健康对照者（A组）和105名尿失禁女性。35名女性患有压力性尿失禁（B组），35名女性患有混合性尿失禁（C组），35名膀胱过度活动症患者无论有无漏尿（D组）。所有参与者均被要求进行3次UFM测量。分析以下参数：排尿量（VV）、峰值尿流率（Q）、平均尿流率（Q）、经排尿量校正的峰值尿流率cQ（cQ = Q/√VV）、经排尿量校正的平均尿流率（cQ = Q/√VV）以及残余尿量（PVR）。采用重复测量方差分析进行统计分析。相对误差使用变异系数计算，变异系数以平均值的百分比表示。所有描述性特征均以均值±标准差（SD）报告。p值≤0.05被认为具有统计学意义。
在A组、C组和D组的三次UFM记录中，未发现任何记录参数存在统计学显著的个体内差异。在压力性尿失禁患者（B组）中，以下参数的个体内变异性达到统计学显著水平：Q（p = 0.0016）、Q（p = 0.0005）和cQ（p = 0.0389）。仅在连续的第一次和第二次记录比较中观察到显著差异。
本研究提供了支持UFM高可靠性和良好个体内可重复性的证据。
