Center for Genome Engineering, Institute for Basic Science, Seoul, Republic of Korea.
Department of Chemistry, Seoul National University, Seoul, Republic of Korea.
Nat Plants. 2018 Mar;4(3):148-151. doi: 10.1038/s41477-018-0115-z. Epub 2018 Feb 26.
Adenine base editors (ABEs), composed of an engineered deaminase and a catalytically impaired CRISPR-Cas9 variant, are powerful new tools for targeted base editing in cells and organisms. Together with cytosine base editors (CBEs), ABEs enable single-nucleotide conversions cleanly, efficiently and reversibly without double-stranded DNA cleavage, advancing genome editing in a new dimension.
腺嘌呤碱基编辑器（ABEs）由一种工程化的脱氨酶和一种催化失活的 CRISPR-Cas9 变体组成，是在细胞和生物体内进行靶向碱基编辑的强大新工具。ABEs 与胞嘧啶碱基编辑器（CBEs）一起，可以在不进行双链 DNA 切割的情况下，高效、可逆地实现单核苷酸转换，将基因组编辑推进到一个新的维度。
