BRAF 激活的非编码 RNA：人类恶性肿瘤中关键的长非编码 RNA。
The BRAF activated non-coding RNA: A pivotal long non-coding RNA in human malignancies.
机构信息
Department of Ophthalmology, The First Hospital of Jilin University, Jilin, China.
Department of. Neurosurgery, The People's Hospital of Jilin Province, Jilin, China.
出版信息
Cell Prolif. 2018 Aug;51(4):e12449. doi: 10.1111/cpr.12449. Epub 2018 Feb 27.
Abstract
Long non-coding RNAs (lncRNAs) participate in the complex network of cancer and play an important role in tumourigenesis and progression. BRAF activated non-coding RNA (BANCR), a 4-exon transcript of 693-bp, was first discovered as an oncogenic long non-coding RNA in BRAF melanomas cells in 2012 and was related to melanoma cell migration. Besides melanoma, increasing evidence has explored the potential role of BANCR in the development and progression of multiple other human malignancies, such as retinoblastoma, lung cancer, gastric cancer etc. since its discovery. The expression pattern of BANCR varies in different types of cancers, either as a tumour suppressor or as an accelerator. Functional BANCR may serve as a promising biomarker for cancer diagnosis as well as prognosis evaluation. BANCR-targeted intervention may also become a valuable novel therapeutic tool against human malignancies. This review summarized the advanced research progresses concerning the expression and role of BANCR in different human malignancies.
摘要
长链非编码 RNA（lncRNAs）参与癌症的复杂网络，在肿瘤发生和进展中发挥重要作用。BRAF 激活的非编码 RNA（BANCR）是一种 693bp 的 4 外显子转录本，于 2012 年首次在 BRAF 黑色素瘤细胞中被发现为致癌的长非编码 RNA，与黑色素瘤细胞迁移有关。除黑色素瘤外，自发现以来，越来越多的证据探索了 BANCR 在多种其他人类恶性肿瘤（如视网膜母细胞瘤、肺癌、胃癌等）中的潜在作用。BANCR 的表达模式在不同类型的癌症中不同，既可以作为肿瘤抑制因子，也可以作为肿瘤促进因子。功能性 BANCR 可能作为癌症诊断和预后评估的有前途的生物标志物。BANCR 靶向干预也可能成为针对人类恶性肿瘤的有价值的新型治疗工具。本综述总结了有关 BANCR 在不同人类恶性肿瘤中的表达和作用的最新研究进展。
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