Friedman Elisheva, Alizadeh Negin, Loewy Zvi
Department of Pharmaceutical and Biomedical Sciences, Touro College of Pharmacy, New York, NY 10027, USA.
Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA.
High Throughput. 2017 Aug 1;6(3):11. doi: 10.3390/ht6030011.
This study aims to consider the microbial distribution in oral disease, as well as gene analysis and expression, in elucidating: 1, the fundamental underpinnings of oral disease, and 2, the potential relationship between oral diseases and systemic health. A key focus is identifying the microbiota associated with oral disease manifestations characterized by both conventional microbiological and molecular methods. Variations in the observed microbial populations characterized by conventional and molecular approaches have been identified for caries, periodontitis, peri-implantitis, and stomatitis. The discovery of therapeutic approaches for oral disease will require comprehensive microbial and genomic analysis. This study evaluated the current state of the relevant microbial and genomic information for several prevalent oral diseases.
本研究旨在通过考虑口腔疾病中的微生物分布以及基因分析和表达，来阐明：1. 口腔疾病的基本成因；2. 口腔疾病与全身健康之间的潜在关系。一个关键重点是通过传统微生物学和分子方法识别与口腔疾病表现相关的微生物群。对于龋齿、牙周炎、种植体周围炎和口腔炎，已经确定了通过传统方法和分子方法观察到的微生物种群的差异。口腔疾病治疗方法的发现需要全面的微生物和基因组分析。本研究评估了几种常见口腔疾病的相关微生物和基因组信息的现状。
