Laboratory of Molecular Environmental Microbiology, Department of Environmental Science and Ecological Engineering, Korea University, Seoul, 02841, Republic of Korea.
J Microbiol. 2018 Mar;56(3):151-153. doi: 10.1007/s12275-018-0577-8.
The host genetic background, complex surrounding environments, and gut microbiome are very closely linked to human and animal health and disease. Although significant correlations between gut microbiota and human and animal health have been revealed, the specific roles of each gut bacterium in shaping human and animal health and disease remain unclear. However, recent omics-based studies using experimental animals and surveys of gut microbiota from unhealthy humans have provided insights into the relationships among microbial community, their metabolites, and human and animal health. This editorial introduces six review papers that provide new discoveries of disease-associated microbiomes and suggest possible microbiome-based therapeutic approaches to human disease.
宿主遗传背景、复杂的周围环境和肠道微生物组与人类和动物的健康和疾病密切相关。尽管已经揭示了肠道微生物群与人类和动物健康之间存在显著相关性，但每种肠道细菌在塑造人类和动物健康和疾病方面的具体作用仍不清楚。然而，最近使用实验动物的组学研究和对不健康人类肠道微生物组的调查，为微生物群落、它们的代谢物与人类和动物健康之间的关系提供了新的认识。本社论介绍了六篇综述文章，这些文章提供了与疾病相关的微生物组的新发现，并提出了可能基于微生物组的治疗人类疾病的方法。
