利用宏基因组学来描绘不断扩展的病毒圈。
Using Metagenomics to Characterize an Expanding Virosphere.
机构信息
Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Fudan University, Shanghai, China; State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Beijing, China.
Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Fudan University, Shanghai, China; State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Beijing, China; Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life and Environmental Sciences and Sydney Medical School, The University of Sydney, Sydney, Australia.
出版信息
Cell. 2018 Mar 8;172(6):1168-1172. doi: 10.1016/j.cell.2018.02.043.
We know less about viruses than any other lifeform. Fortunately, metagenomics has led to a massive expansion in the known diversity of the virosphere. Here, we discuss how metagenomics has changed our understanding of RNA viruses and present some of the remaining challenges, including characterization of the "dark matter" of divergent viral genomes.
我们对病毒的了解比其他任何生命形式都要少。幸运的是，宏基因组学使人们对病毒圈的已知多样性有了巨大的扩展。在这里，我们讨论了宏基因组学如何改变了我们对 RNA 病毒的理解，并提出了一些仍然存在的挑战，包括对分化病毒基因组的“暗物质”的特征描述。
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