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用树突状细胞进行预刺激可阻止经脱氧鸟苷处理的胎儿胸腺同种异体移植物的存活。

Survival of deoxyguanosine-treated fetal thymus allografts is prevented by priming with dendritic cells.

作者信息

Benson M T, Buckley G, Jenkinson E J, Owen J J

出版信息

Immunology. 1987 Apr;60(4):593-6.

PMID:2953671
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1453289/
Abstract

Allogeneic thymus lobes rendered alymphoid by treatment with deoxyguanosine are not rejected in normal mice despite expression of class I and class II MHC antigens on donor cells. The results presented here show that the injection of as few as 10,000 cells from dendritic cell-enriched populations is followed by the rejection of deoxyguanosine-treated grafts. These findings support the notion that treated thymus grafts do not provoke rejection because they lack dendritic cells, which are destroyed by deoxyguanosine.

摘要

用脱氧鸟苷处理后变为无淋巴细胞的同种异体胸腺叶，尽管供体细胞上表达了I类和II类MHC抗原，但在正常小鼠中不会被排斥。此处呈现的结果表明，注射来自富含树突状细胞群体的低至10000个细胞后，脱氧鸟苷处理的移植物会被排斥。这些发现支持了这样一种观点，即经处理的胸腺移植物不会引发排斥反应，因为它们缺乏被脱氧鸟苷破坏的树突状细胞。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6366/1453289/231d12950264/immunology00173-0106-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6366/1453289/231d12950264/immunology00173-0106-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6366/1453289/231d12950264/immunology00173-0106-a.jpg

相似文献

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Survival of deoxyguanosine-treated fetal thymus allografts is prevented by priming with dendritic cells.用树突状细胞进行预刺激可阻止经脱氧鸟苷处理的胎儿胸腺同种异体移植物的存活。
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引用本文的文献

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The role of graft-derived dendritic leukocytes in the rejection of vascularized organ allografts. Recent findings on the migration and function of dendritic leukocytes after transplantation.移植来源的树突状白细胞在血管化器官同种异体移植排斥反应中的作用。关于移植后树突状白细胞迁移和功能的最新研究发现。

本文引用的文献

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Restoration of immunogenicity to passenger cell-depleted kidney allografts by the addition of donor strain dendritic cells.通过添加供体品系树突状细胞恢复去除过客细胞的肾移植异体移植物的免疫原性。
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Prolongation of murine islet allograft survival by pretreatment of islets with antibody directed to Ia determinants.用针对Ia决定簇的抗体预处理胰岛可延长小鼠胰岛同种异体移植的存活时间。
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Rat thymic cultures: morphological and phenotypical characterization.大鼠胸腺培养物：形态学和表型特征
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同种异体胰岛移植在无免疫抑制情况下逆转糖尿病
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4
Successful transplantation across major histocompatibility barrier of deoxyguanosine-treated embryonic thymus expressing class II antigens.经脱氧鸟苷处理的表达II类抗原的胚胎胸腺跨越主要组织相容性屏障的成功移植。
Nature. 1984;310(5974):231-3. doi: 10.1038/310231a0.
5
Gene transfer of H-2 class II genes: antigen presentation by mouse fibroblast and hamster B-cell lines.H-2 Ⅱ类基因的基因转移：小鼠成纤维细胞和仓鼠 B 细胞系的抗原呈递
Cell. 1984 Feb;36(2):319-27. doi: 10.1016/0092-8674(84)90225-3.
6
Induction of immune responses in vivo with small numbers of veiled (dendritic) cells.利用少量面纱样（树突状）细胞在体内诱导免疫反应。
Proc Natl Acad Sci U S A. 1983 Oct;80(19):6032-5. doi: 10.1073/pnas.80.19.6032.
7
Prolongation of rat islet allograft survival by direct ultraviolet irradiation of the graft.通过对大鼠胰岛移植体进行直接紫外线照射延长其存活时间。
Science. 1984 Feb 10;223(4636):607-9. doi: 10.1126/science.6420888.
8
Epithelial cells expressing aberrant MHC class II determinants can present antigen to cloned human T cells.表达异常MHC II类决定簇的上皮细胞可将抗原呈递给克隆化的人T细胞。
Nature. 1984;312(5995):639-41. doi: 10.1038/312639a0.
9
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J Immunol. 1984 Jun;132(6):2749-59.