Woskie Susan, Kongtip Pornpimol, Thanasanpaiboon Wiroj, Kiatdamrong Napaporn, Charoonrungsirikul Nantha, Nankongnab Noppanun, Surach Anu, Phamonphon Akkarat
a Department of Work Environment , University of Massachusetts Lowell , Lowell , MA , USA.
b Faculty of Public Health, Department of Occupational Health and Safety , Mahidol University , Bangkok , Thailand.
Int J Occup Environ Health. 2017 Jul;23(3):193-201. doi: 10.1080/10773525.2018.1450324. Epub 2018 Mar 15.
The objective of this study was to evaluate whether prenatal exposures to organophosphate (OP) pesticides from maternal agricultural use are associated with neonatal neurobehavioral effects. A pilot study conducted in three provinces in Thailand measured maternal urinary metabolites of OP pesticides in pregnant women at 7 months gestation and at birth. Within 3 days of birth, 82 newborns underwent neurobehavioral testing using the Brazelton Neonatal Behavioral Assessment Scale (NBAS). Comparison of the NBAS test results with maternal OP metabolite levels found the neonates NBAS Habituation cluster score increased with maternal dimethylphosphate (DMP) levels (p = 0.04) while the Range of State score increased with total diethylphosphate (DEP) levels (p = 0.01). The Number of Abnormal Reflexes in the neonate also increased as maternal urinary total DEP levels increased (p = 0.06). These preliminary findings suggest that pre-natal exposures to OP pesticides can impact newborn neurodevelopment and support the need for a longitudinal evaluation of childhood neurodevelopment in relation to pesticide exposures in Thailand.
本研究的目的是评估孕期母亲从事农业活动所接触的有机磷（OP）农药是否与新生儿神经行为效应有关。在泰国三个省份开展的一项初步研究，测量了妊娠7个月时及分娩时孕妇尿液中OP农药的代谢物。出生后3天内，82名新生儿使用布雷泽尔顿新生儿行为评估量表（NBAS）进行了神经行为测试。将NBAS测试结果与母亲OP代谢物水平进行比较发现，新生儿NBAS习惯化集群评分随母亲二甲基磷酸酯（DMP）水平升高而增加（p = 0.04），而状态范围评分随总二乙基磷酸酯（DEP）水平升高而增加（p = 0.01）。随着母亲尿液中总DEP水平升高，新生儿异常反射数量也增加（p = 0.06）。这些初步研究结果表明，产前接触OP农药会影响新生儿神经发育，并支持有必要对泰国儿童期神经发育与农药接触之间的关系进行纵向评估。
