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Prenatal exposure to organophosphate pesticides and functional neuroimaging in adolescents living in proximity to pesticide application.产前接触有机磷农药与临近施药地区青少年的功能神经影像学
Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18347-18356. doi: 10.1073/pnas.1903940116. Epub 2019 Aug 26.
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Organophosphate Pesticide Exposure in Pregnancy in Association with Ultrasound and Delivery Measures of Fetal Growth.孕期接触有机磷农药与胎儿生长的超声及分娩测量指标的关系。
Environ Health Perspect. 2019 Aug;127(8):87005. doi: 10.1289/EHP4858. Epub 2019 Aug 16.
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Effects of prenatal and postnatal exposure to organophosphate pesticides on child neurodevelopment in different age groups: a systematic review.产前和产后暴露于有机磷农药对不同年龄组儿童神经发育的影响：系统评价。
Environ Sci Pollut Res Int. 2019 Jun;26(18):18267-18290. doi: 10.1007/s11356-019-05126-w. Epub 2019 Apr 30.
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Organophosphate exposures during pregnancy and child neurodevelopment: Recommendations for essential policy reforms.孕期接触有机磷农药与儿童神经发育：基本政策改革建议。
PLoS Med. 2018 Oct 24;15(10):e1002671. doi: 10.1371/journal.pmed.1002671. eCollection 2018 Oct.
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Neurotoxicity in acute and repeated organophosphate exposure.急性和重复有机磷暴露的神经毒性。
Toxicology. 2018 Sep 1;408:101-112. doi: 10.1016/j.tox.2018.08.011. Epub 2018 Aug 23.
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A pilot study of maternal exposure to organophosphate pesticides and newborn neurodevelopment in Thailand.泰国孕妇接触有机磷农药与新生儿神经发育的一项初步研究。
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Environ Int. 2017 Sep;106:248-256. doi: 10.1016/j.envint.2017.05.015. Epub 2017 Jun 8.
8
Effects of simultaneous prenatal exposures to organophosphate and synthetic pyrethroid insecticides on infant neurodevelopment at three months of age.孕期同时接触有机磷和拟除虫菊酯类杀虫剂对三个月大婴儿神经发育的影响。
J Environ Toxicol Public Health. 2016 May;1:60-73. doi: 10.5281/zenodo.218417. Epub 2016 May 19.
9
The Impact of Prenatal Organophosphate Pesticide Exposures on Thai Infant Neurodevelopment.产前有机磷农药暴露对泰国婴儿神经发育的影响。
Int J Environ Res Public Health. 2017 May 27;14(6):570. doi: 10.3390/ijerph14060570.
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Neurotoxicity in Preclinical Models of Occupational Exposure to Organophosphorus Compounds.职业性接触有机磷化合物临床前模型中的神经毒性
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孕期早期和晚期接触有机磷农药会影响婴儿发育表现的不同方面。

Organophosphate Pesticide Exposures in Early and Late Pregnancy Influence Different Aspects of Infant Developmental Performance.

作者信息

Suwannakul Boonsita, Sapbamrer Ratana, Wiwattanadittakul Natrujee, Hongsibsong Surat

机构信息

Department of Community Medicine, Faculty of Medicine, Chiang Mai University, 110 Inthavaroros, Sri Phum Subdistrict, Muang District, Chiang Mai 50200, Thailand.

Environmental and Occupational Health Sciences and Non Communicable Diseases Center of Excellence, Chiang Mai University, 110 Inthavaroros Road, Sriphum Subdistrict, Muang District, Chiang Mai 50200, Thailand.

出版信息

Toxics. 2021 Apr 30;9(5):99. doi: 10.3390/toxics9050099.

DOI:10.3390/toxics9050099
PMID:33946194
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8145728/
Abstract

Organophosphate (OP) pesticides can transfer from mother to fetus via the placenta and amniotic fluid and may affect the development of infants. This study aims to evaluate the associations between maternal OP concentrations collected in the 1st-2nd trimester and the 3rd trimester of pregnancy and the infant developmental performance. The Screening Test of the Bayley Scales of Infants and Toddler Development, Third Edition (BSID-III screening test) was used to assess development performance at 2 and 6 months of age. Multiple regression analysis showed a negative correlation between cognitive performance at 2 months and maternal diethylthiophosphate (DETP) levels in the 1st-2nd trimester ( ± SE = -0.012 ± 0.004, < 0.05). We also found that expressive communication and fine motor performance at 6 months were negatively associated with maternal diethyldithiophosphate (DEDTP) levels in the 3rd trimester ( ± SE = -0.047 ± 0.016, < 0.05, and ± SE = -0.044 ± 0.017, < 0.05, respectively). These results suggest that maternal ethylated OP concentrations at different timing of exposure during pregnancy may influence different aspects of infant developmental performance.

摘要

有机磷酸酯（OP）农药可通过胎盘和羊水从母体转移至胎儿，可能影响婴儿发育。本研究旨在评估孕期第1 - 2孕期和第3孕期采集的母体OP浓度与婴儿发育表现之间的关联。使用贝利婴幼儿发展量表第三版筛查测试（BSID - III筛查测试）评估2个月和6个月大时的发育表现。多元回归分析显示，2个月时的认知表现与第1 - 2孕期母体二乙基硫代磷酸酯（DETP）水平呈负相关（±SE = -0.012 ± 0.004，P < 0.05）。我们还发现，6个月时的表达性沟通和精细运动表现与第3孕期母体二乙基二硫代磷酸酯（DEDTP）水平呈负相关（分别为±SE = -0.047 ± 0.016，P < 0.05，以及±SE = -0.044 ± 0.017，P < 0.05）。这些结果表明，孕期不同暴露时间的母体乙基化OP浓度可能影响婴儿发育表现的不同方面。