Department of Breast surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.
Anhui Medical University, Hefei, 230000, China.
BMC Cancer. 2018 Mar 20;18(1):305. doi: 10.1186/s12885-018-4207-y.
To investigate the relationship between time elapsed since completion of radiotherapy (RT) and quality of life (QOL) of patients with breast cancer.
A total of 300 patients with breast cancer were treated at the First Affiliated Hospital of Anhui Medical University between January 2013 and April 2016. Of these, 212 patients were included in the study. Patients were divided into 4 groups based on the time elapsed since completion of RT. The generic cancer questionnaire, EORTC QLQ-30, and the breast cancer-specific questionnaire, QLQ-BR23, were used to assess the QOL.
Analysis of time elapsed since completion of RT and QOL revealed changes in the scores for role function with passage of time; the third year's scores were the highest. Pain symptoms during the 3rd and 4th years after RT were lower than those during the 1st and 2nd years after RT; scores for financial difficulties fluctuated with passage of time; perception of own body scores improved within first 3 years; sexual activity and enjoyment of sexual activity showed a significant decrease during the 2nd to 4th year post RT. Scores pertaining to concerns about future state of health showed a significant increase during the 2nd to 4th year after RT, while breast symptoms score showed fluctuations with passage of time.
Social function, pain symptoms, and concerns about future state of health tended to improve with passage of time after RT. Other scales showed no correlation with time elapsed since completion of RT.
研究乳腺癌患者放疗结束后时间与生活质量（QOL）的关系。
收集 2013 年 1 月至 2016 年 4 月在安徽医科大学第一附属医院治疗的 300 例乳腺癌患者的临床资料，其中 212 例患者纳入研究。根据放疗结束后的时间将患者分为 4 组。采用通用癌症问卷 EORTC QLQ-C30 及乳腺癌特异性问卷 QLQ-BR23 评估患者的生活质量。
分析放疗结束后时间与 QOL 的关系，发现角色功能评分随时间推移而变化，第 3 年最高；疼痛症状在放疗后第 3 年和第 4 年比第 1 年和第 2 年低；经济困难评分随时间波动；对自身身体状况的认知评分在第 1 至 3 年有所提高；放疗后第 2 至 4 年性活动和性享受显著下降；对未来健康状况的担忧评分在放疗后第 2 至 4 年显著增加，而乳房症状评分随时间波动。
放疗后，社会功能、疼痛症状和对未来健康状况的担忧随时间推移而改善。其他量表与放疗结束后的时间无相关性。
