Department of Chemistry, Chemistry Research Laboratory , University of Oxford , 12 Mansfield Road , Oxford OX1 3TA , United Kingdom.
Chemistry Branch, Department of Science and Mathematics, Faculty of Petroleum and Mining Engineering , Suez University , Suez 43721 , Egypt.
ACS Nano. 2018 Apr 24;12(4):3333-3340. doi: 10.1021/acsnano.7b08620. Epub 2018 Mar 20.
The design of nanoparticulate systems which can perform multiple synergistic functions in cells with high specificity and selectivity is of great importance in applications. Here we combine recent advances in DNA-gold nanoparticle self-assembly and sensing to develop gold nanoparticle dimers that are able to perform multiplexed synergistic functions within a cellular environment. These dimers can sense two mRNA targets and simultaneously or independently deliver one or two DNA-intercalating anticancer drugs (doxorubicin and mitoxantrone) in live cells. Our study focuses on the design of sophisticated nanoparticle assemblies with multiple and synergistic functions that have the potential to advance sensing and drug delivery in cells.
设计能够在细胞中具有高特异性和选择性地执行多种协同功能的纳米颗粒系统在应用中非常重要。在这里，我们结合 DNA-金纳米粒子自组装和传感方面的最新进展，开发出能够在细胞环境中执行多重协同功能的金纳米粒子二聚体。这些二聚体能够同时或独立地检测两种 mRNA 靶标，并在活细胞中递送电穿孔和非电穿孔两种 DNA 嵌入型抗癌药物（阿霉素和米托蒽醌）。我们的研究重点是设计具有多种协同功能的复杂纳米颗粒组装体，这有可能推进细胞中的传感和药物传递。
