Varona Luis, Legarra Andres, Toro Miguel A, Vitezica Zulma G
Departamento de Anatomía, Embriología y Genética Animal, Universidad de Zaragoza, Zaragoza, Spain.
Instituto Agroalimentario de Aragón (IA2), Zaragoza, Spain.
Front Genet. 2018 Mar 6;9:78. doi: 10.3389/fgene.2018.00078. eCollection 2018.
In the last decade, genomic selection has become a standard in the genetic evaluation of livestock populations. However, most procedures for the implementation of genomic selection only consider the additive effects associated with SNP (Single Nucleotide Polymorphism) markers used to calculate the prediction of the breeding values of candidates for selection. Nevertheless, the availability of estimates of non-additive effects is of interest because: (i) they contribute to an increase in the accuracy of the prediction of breeding values and the genetic response; (ii) they allow the definition of mate allocation procedures between candidates for selection; and (iii) they can be used to enhance non-additive genetic variation through the definition of appropriate crossbreeding or purebred breeding schemes. This study presents a review of methods for the incorporation of non-additive genetic effects into genomic selection procedures and their potential applications in the prediction of future performance, mate allocation, crossbreeding, and purebred selection. The work concludes with a brief outline of some ideas for future lines of that may help the standard inclusion of non-additive effects in genomic selection.
在过去十年中,基因组选择已成为家畜群体遗传评估的标准。然而,大多数实施基因组选择的程序仅考虑与用于计算候选选择个体育种值预测的单核苷酸多态性(SNP)标记相关的加性效应。尽管如此,非加性效应估计值的可用性仍备受关注,原因如下:(i)它们有助于提高育种值预测和遗传反应的准确性;(ii)它们允许定义候选选择个体之间的交配分配程序;(iii)它们可用于通过定义适当的杂交或纯种育种方案来增强非加性遗传变异。本研究综述了将非加性遗传效应纳入基因组选择程序的方法及其在未来性能预测、交配分配、杂交和纯种选择中的潜在应用。文章最后简要概述了一些未来的思路,这些思路可能有助于将非加性效应标准纳入基因组选择。