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考虑非加性遗传效应的基因组预测方法。

Genomic Prediction Methods Accounting for Nonadditive Genetic Effects.

作者信息

Varona Luis, Legarra Andres, Toro Miguel A, Vitezica Zulma G

机构信息

Departamento de Anatomía, Embriología y Genética Animal, Universidad de Zaragoza, Zaragoza, Spain.

Instituto Agroalimentario de Aragón (IA2), Zaragoza, Spain.

出版信息

Methods Mol Biol. 2022;2467:219-243. doi: 10.1007/978-1-0716-2205-6_8.

Abstract

The use of genomic information for prediction of future phenotypes or breeding values for the candidates to selection has become a standard over the last decade. However, most procedures for genomic prediction only consider the additive (or substitution) effects associated with polymorphic markers. Nevertheless, the implementation of models that consider nonadditive genetic variation may be interesting because they (1) may increase the ability of prediction, (2) can be used to define mate allocation procedures in plant and animal breeding schemes, and (3) can be used to benefit from nonadditive genetic variation in crossbreeding or purebred breeding schemes. This study reviews the available methods for incorporating nonadditive effects into genomic prediction procedures and their potential applications in predicting future phenotypic performance, mate allocation, and crossbred and purebred selection. Finally, a brief outline of some future research lines is also proposed.

摘要

在过去十年中,利用基因组信息预测候选选择对象的未来表型或育种值已成为一种标准做法。然而,大多数基因组预测程序仅考虑与多态性标记相关的加性(或替代)效应。尽管如此,考虑非加性遗传变异的模型的应用可能会很有意义,因为它们(1)可能会提高预测能力,(2)可用于确定动植物育种方案中的交配分配程序,以及(3)可用于在杂交或纯种育种方案中利用非加性遗传变异。本研究综述了将非加性效应纳入基因组预测程序的现有方法及其在预测未来表型表现、交配分配以及杂交和纯种选择方面的潜在应用。最后,还提出了一些未来研究方向的简要概述。

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