接种于支架上的间充质干细胞在关节软骨修复中的应用。
Use of mesenchymal stem cells seeded on the scaffold in articular cartilage repair.
作者信息
Yamagata Kaoru, Nakayamada Shingo, Tanaka Yoshiya
机构信息
The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Yahata-nishi-ku, Kitakyushu, 807-8555 Japan.
出版信息
Inflamm Regen. 2018 Mar 12;38:4. doi: 10.1186/s41232-018-0061-1. eCollection 2018.
Abstract
Articular cartilage has poor capacity for repair. Once damaged, they degenerate, causing functional impairment of joints. Allogeneic cartilage transplantation has been performed for functional recovery of articular cartilage. However, there is only a limited amount of articular cartilage available for transplantation. Mesenchymal stem cells (MSCs) could be potentially suitable for local implantation. MSCs can differentiate into chondrocytes. Several studies have demonstrated the therapeutic potential of MSCs in the repair of articular cartilage in animal models of articular cartilage damage and in patients with damaged articular cartilage. To boost post-implantation MSC differentiation into chondrocytes, the alternative delivery methods by scaffolds, using hyaluronic acid (HA) or poly-lactic-co-glycolic-acid (PLGA), have developed. In this review, we report recent data on the repair of articular cartilage and discuss future developments.
摘要
关节软骨的修复能力较差。一旦受损，它们就会退化，导致关节功能受损。同种异体软骨移植已用于关节软骨的功能恢复。然而，可用于移植的关节软骨数量有限。间充质干细胞（MSCs）可能适合局部植入。MSCs可分化为软骨细胞。多项研究已证明MSCs在关节软骨损伤动物模型和关节软骨受损患者的关节软骨修复中的治疗潜力。为促进植入后MSCs向软骨细胞分化，已开发出使用透明质酸（HA）或聚乳酸-羟基乙酸共聚物（PLGA）的支架替代递送方法。在本综述中，我们报告了关节软骨修复的最新数据并讨论了未来的发展。
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