Division of Tumor Biology & Immunology, Oncode Institute, Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands.
Division of Tumor Biology & Immunology, Oncode Institute, Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands.
Immunity. 2018 Mar 20;48(3):399-416. doi: 10.1016/j.immuni.2018.03.004.
Owing to their tremendous diversity and plasticity, immune cells exert multifaceted functions in tumor-bearing hosts, ranging from anti-tumor to pro-tumor activities. Tumor immune landscapes differ greatly between and within cancer types. Emerging evidence suggests that genetic aberrations in cancer cells dictate the immune contexture of tumors. Here, we review the current understanding of the mechanisms whereby common drivers of tumorigenesis modulate the tumor immune milieu. We discuss these findings in the context of clinical observations and examine how cancer-cell-intrinsic properties can be exploited to maximize the benefit of immunomodulatory therapies. Understanding the relationship between cancer cell-intrinsic genetic events and the immune response may enable personalized immune intervention strategies for cancer patients.
由于其巨大的多样性和可塑性，免疫细胞在肿瘤宿主中发挥着多方面的功能，从抗肿瘤到促肿瘤活性。肿瘤免疫景观在癌症类型之间和内部有很大的差异。新出现的证据表明，癌细胞中的遗传异常决定了肿瘤的免疫结构。在这里，我们回顾了目前对常见肿瘤发生驱动因素调节肿瘤免疫微环境机制的理解。我们将这些发现置于临床观察的背景下，并探讨了如何利用肿瘤细胞内在特性来最大限度地提高免疫调节治疗的益处。了解癌症细胞内在遗传事件与免疫反应之间的关系，可以为癌症患者提供个性化的免疫干预策略。
