Chen Baosong, Li Erwei, Liu Li, Liao Mingfang, Zhu Zhaoxiang, Zhuang Wenying, Bao Li, Liu Hongwei
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, P. R. China.
Savaid Medicine School, University of Chinese Academy of Sciences, Beijing, P. R. China.
Planta Med. 2018 Sep;84(14):1055-1063. doi: 10.1055/a-0593-6030. Epub 2018 Mar 22.
Five new botryane sesquiterpenes (1: -5: ), one new cyclopentadepsipeptide (9: ), and two new xanthones (11: - 12: ), together with 11 known compounds, were isolated from . The structures of the new compounds were identified by comprehensive spectroscopic methods including nuclear magnetic resonance and mass spectrometry. The cytotoxicity of 1: -19: was evaluated against K562, A549, and ASPC cell lines. Compounds 5, 8, 11, 17: , and 18: showed cytotoxicity against the K562 cell line with more than 50% inhibition at 12.5 µM. As to A549 cell line, compound 8: showed the strongest cytotoxicity with approximately 50% inhibition at 25.0 µM. No compounds showed cytotoxicity against the ASPC cell line.
从……中分离出了5种新的贝壳杉烷倍半萜（1：-5：）、1种新的环戊二肽（9：）和2种新的呫吨酮（11：-12：），以及11种已知化合物。通过包括核磁共振和质谱在内的综合光谱方法鉴定了新化合物的结构。评估了1：-19：对K562、A549和ASPC细胞系的细胞毒性。化合物5、8、11、17：和18：对K562细胞系表现出细胞毒性，在12.5µM时抑制率超过50%。对于A549细胞系，化合物8：表现出最强的细胞毒性，在25.0µM时抑制率约为50%。没有化合物对ASPC细胞系表现出细胞毒性。
