Division of Rhinology and Sinus Surgery, Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, SC.
Department of Surgery, Ralph H. Johnson VA Medical Center, Charleston, SC.
Int Forum Allergy Rhinol. 2018 Jul;8(7):783-789. doi: 10.1002/alr.22113. Epub 2018 Mar 23.
Though many patients with chronic rhinosinusitis (CRS) describe disturbances in smell and taste, there have been no studies specifically assessing taste impairment in CRS. This study sought to objectively assess taste dysfunction in CRS patients and determine whether taste impairment correlates with olfactory dysfunction. Additionally, this investigation sought to determine the impact of taste dysfunction on quality of life (QOL) in CRS and identify the clinical factors that influence taste.
Sixty-eight CRS patients were prospectively enrolled and completed several QOL surveys in relation to taste, smell, overall sinus-specific QOL, and depression. Validated taste strips were used to determine gustatory dysfunction pertaining to sweet, sour, salty, and bitter. Olfactory testing was assessed using the Sniffin' Sticks Test while both Lund-Kennedy and Olfactory Cleft Endoscopy Scoring (OCES) systems were used for endoscopic evaluation.
The overall prevalence of dysgeusia was 28%, with scores significantly lower for sour compared to other subgroups. No correlation was observed between taste scores and objective olfactory metrics including olfaction tests and OCES. Taste scores were better in younger patients (r = 0.28, p = 0.02), female patients (p = 0.004), and never smokers compared to former smokers (p = 0.01). Taste scores did not correlate with patient-reported outcome measures or CRS disease severity metrics.
Taste dysfunction is a common complaint in CRS. This cohort shows prevalence of gustatory loss to be about 28% using ideal normative values. This dysfunction correlated with male gender, smoking history, and older age. Taste dysfunction did not correlate with measured olfactory outcomes.
尽管许多慢性鼻-鼻窦炎（CRS）患者都描述了嗅觉和味觉障碍，但目前尚无专门评估 CRS 患者味觉障碍的研究。本研究旨在客观评估 CRS 患者的味觉功能障碍，并确定味觉障碍是否与嗅觉功能障碍相关。此外，本研究还旨在确定味觉障碍对 CRS 患者生活质量（QOL）的影响，并确定影响味觉的临床因素。
68 例 CRS 患者前瞻性入组，并完成了多项与味觉、嗅觉、整体鼻窦特异性 QOL 和抑郁相关的 QOL 调查。使用经过验证的味觉条来确定与甜味、酸味、咸味和苦味相关的味觉功能障碍。使用嗅觉棒测试评估嗅觉测试，同时使用 Lund-Kennedy 和嗅觉裂隙内镜评分（OCES）系统进行内镜评估。
味觉障碍的总体患病率为 28%，酸味的评分明显低于其他亚组。味觉评分与嗅觉测试和 OCES 等客观嗅觉指标之间未观察到相关性。味觉评分在年轻患者（r = 0.28，p = 0.02）、女性患者（p = 0.004）和从不吸烟者中（与前吸烟者相比，p = 0.01）更好。味觉评分与患者报告的结果测量或 CRS 疾病严重程度指标无关。
味觉障碍是 CRS 的常见主诉。本队列研究使用理想的正常参考值显示味觉丧失的患病率约为 28%。这种功能障碍与性别、吸烟史和年龄有关。味觉障碍与测量的嗅觉结果无关。
