Cruickshanks K J, Schubert C R, Snyder D J, Bartoshuk L M, Huang G H, Klein B E K, Klein R, Nieto F J, Pankow J S, Tweed T S, Krantz E M, Moy G S
Department of Ophthalmology, University of Wisconsin, Madison, Wisconsin 53726-2336, USA.
Ann N Y Acad Sci. 2009 Jul;1170:543-52. doi: 10.1111/j.1749-6632.2009.04103.x.
Taste or gustatory function may play an important role in determining diet and nutritional status and therefore indirectly impact health. Yet there have been few attempts to study the spectrum of taste function and dysfunction in human populations. Epidemiologic studies are needed to understand the impact of taste function and dysfunction on public health, to identify modifiable risk factors, and to develop and test strategies to prevent clinically significant dysfunction. However, measuring taste function in epidemiologic studies is challenging and requires repeatable, efficient methods that can measure change over time. Insights gained from translating laboratory-based methods to a population-based study, the Beaver Dam Offspring Study (BOSS) will be shared. In this study, a generalized labeled magnitude scale (gLMS) method was used to measure taste intensity of filter paper disks saturated with salt, sucrose, citric acid, quinine, or 6-n-propylthiouracil, and a gLMS measure of taste preferences was administered. In addition, a portable, inexpensive camera system to capture digital images of fungiform papillae and a masked grading system to measure the density of fungiform papillae were developed. Adult children of participants in the population-based Epidemiology of Hearing Loss Study in Beaver Dam, Wisconsin, are eligible for this ongoing study. The parents were residents of Beaver Dam and 43-84 years of age in 1987-1988; offspring ranged in age from 21-84 years in 2005-2008. Methods will be described in detail and preliminary results about the distributions of taste function in the BOSS cohort will be presented.
味觉或味觉功能在决定饮食和营养状况方面可能发挥重要作用，因此间接影响健康。然而，很少有人尝试研究人群中的味觉功能和功能障碍谱。需要开展流行病学研究，以了解味觉功能和功能障碍对公众健康的影响，确定可改变的风险因素，并制定和测试预防具有临床意义的功能障碍的策略。然而，在流行病学研究中测量味觉功能具有挑战性，需要可重复、高效的方法来测量随时间的变化。本文将分享从基于实验室的方法转化为基于人群的研究（比弗代姆后代研究，BOSS）中获得的见解。在这项研究中，使用广义标记量值量表（gLMS）方法测量用盐、蔗糖、柠檬酸、奎宁或6-正丙基硫氧嘧啶饱和的滤纸圆盘的味觉强度，并进行味觉偏好的gLMS测量。此外，还开发了一种用于拍摄菌状乳头数字图像的便携式、低成本相机系统和一种用于测量菌状乳头密度的盲法分级系统。威斯康星州比弗代姆基于人群的听力损失流行病学研究参与者的成年子女有资格参加这项正在进行的研究。这些父母是比弗代姆的居民，在1987 - 1988年年龄为43 - 84岁；后代在2005 - 2008年年龄范围为21 - 84岁。将详细描述方法，并展示BOSS队列中味觉功能分布的初步结果。
