Textile Research Division, National Research Center, Dokki, Giza, P.O. 12622, Egypt.
Textile Research Division, National Research Center, Dokki, Giza, P.O. 12622, Egypt.
Int J Biol Macromol. 2018 Jul 15;114:929-934. doi: 10.1016/j.ijbiomac.2018.03.149. Epub 2018 Mar 26.
Novel wound dressings composed of non-woven cotton (NWC) fabric and multilayer of hyaluronan (HA) and chitosan were built using layer-by-layer assembly technique. Factors affecting the building up of that dressings such as HA concentration, number of coating layers and nitrogen content of the NWC fabric quaternized form were studied. Meanwhile, some physico-chemical properties of such dressings were investigated. Moreover, to enhance the antibacterial properties of the aforementioned dressings, Silver nano-particles (Ag NPs) were prepared and incorporated as a functional additive in the final HA layer of such dressings. Factors affecting the building up of that dressings such as HA concentration, number of coating layers and nitrogen content of the NWC fabric quaternized form were studied. The results obtained showed that: i) increasing of HA concentration from 0.25 to 1.0% is accompanied by a gradual reduction in the swelling properties and an improvement in the gel fractionas as well as antibacterial properties of treated fabric along with a decreasing in extents of stiffness, air permeability and the relative water vapor permeability of treated fabric, ii) increasing of steeping time of coated samples results in an improvement in percent swelling of these samples. TEM image of the prepared Ag-NPs depicts that the particle size of that nano-particles was <13nm. Furthermore, the prepared dressing surface was characterized via scanning electron microscope. The EDX of Ag NPs loaded dressings confirmed the presence of Ag NPs onto such dressings with Ag - content of 0.24% (w/w). The thermogravimetric analysis assured that the prepared dressings based on quaternized NWC fabric have higher thermal stability than the un-quaternized form.
新型伤口敷料由无纺棉（NWC）织物和多层透明质酸（HA）和壳聚糖组成，采用层层组装技术构建。研究了影响敷料构建的因素，如 HA 浓度、涂层层数和季铵化 NWC 织物的氮含量。同时，研究了这种敷料的一些物理化学性质。此外，为了提高上述敷料的抗菌性能，制备了银纳米粒子（Ag NPs）并作为功能添加剂掺入到敷料的最终 HA 层中。研究了影响敷料构建的因素，如 HA 浓度、涂层层数和季铵化 NWC 织物的氮含量。结果表明：i）HA 浓度从 0.25%增加到 1.0%时，处理过的织物的溶胀性能逐渐降低，凝胶分数以及抗菌性能得到改善，同时处理过的织物的硬度、透气性和相对水蒸气透过率降低，ii）增加涂层样品的浸泡时间会提高这些样品的溶胀率。TEM 图像显示，这些纳米粒子的粒径<13nm。此外，还对制备的敷料表面进行了扫描电子显微镜表征。载银纳米粒子的 EDX 证实了银纳米粒子存在于这些敷料上，银含量为 0.24%（w/w）。热重分析确保了基于季铵化 NWC 织物的制备敷料比未季铵化形式具有更高的热稳定性。
