Qu Di, Venzon Dawna, Murray Mary, Depauw Mathew
Amway R&D, Ada, MI.
J Cosmet Sci. 2017 May/Jun;68(3):195-204.
Using skin autofluorescence (SAF) as a marker of advanced glycation end-products (AGEs) has been extensively studied in the last decade since the introduction of the noninvasive measurement technique. Data have shown the level of skin AGEs increases with chronological age in healthy human beings, and this increase is substantially higher in age-matched diabetic patients. In skin research, glycation with the accompanying accumulation of skin AGEs has been regarded as one of the primary skin aging mechanisms that contribute to skin wrinkling and the loss of skin elasticity. To date, the totality of SAF data reported in literature has been obtained from measurements on the arm, and noninvasive measurement of facial skin AGE accumulation would add great value to skin aging research. In this study, we report the levels of facial and forearm skin AGEs in 239 men and women of 21-65 year of age. Significantly lower levels of AGEs were detected in the facial skin than in the forearm skin from the young Caucasian groups, and the difference was much larger for men than for women. The rate of change in skin AGE level over age was found to be about 50% higher in men than in women, which further highlights the gender difference. A statistically significant correlation between the levels of skin AGE and facial wrinkling was also observed. The facial skin AGE data may provide new insight into skin aging research.
自无创测量技术问世以来，在过去十年中，使用皮肤自发荧光（SAF）作为晚期糖基化终产物（AGEs）的标志物已得到广泛研究。数据表明，在健康人群中，皮肤AGEs水平随实际年龄增长而升高，且在年龄匹配的糖尿病患者中，这种升高幅度更大。在皮肤研究中，糖基化以及随之而来的皮肤AGEs积累被视为导致皮肤皱纹和皮肤弹性丧失的主要皮肤老化机制之一。迄今为止，文献中报道的所有SAF数据均来自于对手臂的测量，而对面部皮肤AGE积累的无创测量将为皮肤老化研究增添巨大价值。在本研究中，我们报告了239名年龄在21至65岁之间的男性和女性面部及前臂皮肤AGEs的水平。在年轻的白人群体中，面部皮肤检测到的AGEs水平显著低于前臂皮肤，且男性的差异比女性大得多。发现男性皮肤AGE水平随年龄的变化率比女性高约50%，这进一步凸显了性别差异。还观察到皮肤AGE水平与面部皱纹之间存在统计学上的显著相关性。面部皮肤AGE数据可能为皮肤老化研究提供新的见解。
