LG Household & Health Care, LG Science Park, Seoul, Korea.
J Cosmet Dermatol. 2021 Sep;20(9):2963-2968. doi: 10.1111/jocd.13943. Epub 2021 Feb 1.
The accumulation of advanced glycation end products has been proposed as a causative agent of skin aging, but there are no conventional devices for quantifying advanced glycation end-product accumulation in facial skin.
This study aimed to develop a convenient and accurate in situ advanced glycation end-product measurement system for the human face.
We developed a facial glycation imaging system, which consisted of illumination (white light-emitting diode, ultraviolet light-emitting diode) and image acquisition modules to capture face images. Advanced glycation end product-related autofluorescence and total skin reflectance were calculated to obtain the skin glycation index using an image analysis algorithm. Correlations between the skin glycation index and facial skin elasticity and age were examined in 36 healthy Korean women.
The facial glycation imaging system was validated against a volar forearm skin autofluorescence measurement device, that is, the AGE Reader mu, with forearm skin glycation index (R = 0.64, P < .01). Cheek elasticity was negatively correlated with cheek skin glycation index (R = -0.56, R = -0.57, and R = -0.61, P < .01 for R2, R5, and R7, respectively). Age was significantly correlated with forearm skin glycation index (R = 0.44, P < .01) and cheek skin glycation index (R = 0.48, P < .01).
We successfully developed a novel in situ facial skin glycation index measurement device. Our convenient and accurate system enables in situ skin glycation index monitoring for skin aging studies such as those on anti-glycation cosmetics.
已有研究提出，糖基化终产物的积累是皮肤衰老的一个致病因素，但目前还没有常规设备可定量检测面部皮肤中的糖基化终产物积累。
本研究旨在开发一种用于人体面部的方便、准确的原位糖基化终产物测量系统。
我们开发了一种面部糖化成像系统，该系统由照明（白色发光二极管、紫外线发光二极管）和图像采集模块组成，用于捕获面部图像。使用图像分析算法计算糖基化终产物相关的自发荧光和总皮肤反射率，以获得皮肤糖化指数。在 36 名健康的韩国女性中，检测了皮肤糖化指数与面部皮肤弹性和年龄之间的相关性。
面部糖化成像系统与手掌皮肤自发荧光测量设备（即 AGE Reader mu）进行了验证，手掌皮肤糖化指数的相关性为 R=0.64，P<0.01。脸颊弹性与脸颊皮肤糖化指数呈负相关（R2= -0.56，R5= -0.57，R7= -0.61，P<0.01）。年龄与前臂皮肤糖化指数（R=0.44，P<0.01）和脸颊皮肤糖化指数（R=0.48，P<0.01）均呈显著相关。
我们成功开发了一种新型的原位面部皮肤糖化指数测量设备。我们的方便、准确的系统可用于皮肤老化研究，如抗糖化化妆品的研究，实现皮肤糖化指数的原位监测。
