Xin Cong, Wang Yaochi, Liu Mengting, Zhang Bo, Yang Sen
Institute of Dermatology and Department of Dermatology, The First Affiliated Hospital, Anhui Medical University, Hefei, China.
Department of Oncology, The Second Affiliated Hospital, Anhui Medical University, Hefei, China.
J Cosmet Dermatol. 2021 Jan;20(1):243-248. doi: 10.1111/jocd.13452. Epub 2020 May 13.
To investigate the correlation between advanced glycation end products (AGEs) and skin elasticity or blood perfusion values in healthy people of different age groups and to evaluate the relationship between noninvasive detection of AGEs and age or skin aging.
One hundred and two healthy people were enrolled and grouped into groups of 20 years old. Group I: 19-40 years old; Group II: 41-60 years old; Group III: 61-80 years old. Noninvasive techniques such as fluorescence spectroscopy and laser speckle flowmetry were used to detect AGEs levels, local skin perfusion value, and skin elasticity in skin tissue at all age groups.
The AGEs in the skin increased with age, and the difference between the three age groups was statistically significant (P < .05).There was no significant difference in gender between AGEs (P > .05).There was no significant relationship between AGEs and skin elasticity or blood perfusion value in the Group I; there was a low correlation between AGEs and skin elasticity in the 41-60 years age group (r < .4, P < .05). The level of AGEs in the elderly over 60 years was significantly positively correlated with skin elasticity and blooding perfusion value (r > .4, P < .05).
There is a significant correlation between AGEs and age or skin aging indicators. As the age increasing, the level of AGEs increases obviously, which can be used as a potential noninvasive tool for detecting skin aging.
探讨不同年龄组健康人群中晚期糖基化终末产物（AGEs）与皮肤弹性或血液灌注值之间的相关性，并评估AGEs的无创检测与年龄或皮肤老化之间的关系。
招募102名健康人，按20岁一组进行分组。第一组：19 - 40岁；第二组：41 - 60岁；第三组：61 - 80岁。采用荧光光谱法和激光散斑血流仪等无创技术检测所有年龄组皮肤组织中的AGEs水平、局部皮肤灌注值和皮肤弹性。
皮肤中的AGEs随年龄增长而增加，三个年龄组之间的差异具有统计学意义（P <.05）。AGEs在性别上无显著差异（P >.05）。第一组中AGEs与皮肤弹性或血液灌注值之间无显著关系；41 - 60岁年龄组中AGEs与皮肤弹性之间存在低度相关性（r <.4，P <.05）。60岁以上老年人的AGEs水平与皮肤弹性和血液灌注值显著正相关（r >.4，P <.05）。
AGEs与年龄或皮肤老化指标之间存在显著相关性。随着年龄的增长，AGEs水平明显升高，可作为检测皮肤老化的潜在无创工具。
