Lange U
Abteilung Rheumatologie und klinische Immunologie, Kerkhoff-Klinik, Justus-Liebig-Universität Gießen, Benekestr. 2-8, 61231, Bad Nauheim, Deutschland.
Z Rheumatol. 2018 Jun;77(5):379-384. doi: 10.1007/s00393-018-0444-3.
Sarcopenia is an age-related generalized loss of muscle mass and muscle strength resulting in low physical performance, which can be observed in up to 50% of >80-year-old individuals. The consequences are manifold and sarcopenia is closely linked to frailty. Important risk factors are genetics/epigenetics, immobilization, malnutrition and anorexia, hormone deficiencies, chronic inflammation and raised levels of inhibitory factors of tissue regeneration. Thus, functional assessment of muscle strength and physical performance are central components of diagnosing sarcopenia, beyond the mere quantification of muscle mass. Currently, many interventional strategies are being tested, including exercise regimens, nutrition programs, hormone replacement and pharmacological strategies involving anabolic principles. According to the current data, training programs and medications have a high potential.
肌肉减少症是一种与年龄相关的全身性肌肉质量和肌肉力量丧失，导致身体机能下降，在80岁以上的人群中，高达50%的人会出现这种情况。其后果是多方面的，肌肉减少症与身体虚弱密切相关。重要的风险因素包括遗传/表观遗传学、固定不动、营养不良和厌食、激素缺乏、慢性炎症以及组织再生抑制因子水平升高。因此，除了单纯的肌肉质量量化外，肌肉力量和身体机能的功能评估是诊断肌肉减少症的核心组成部分。目前，许多干预策略正在进行测试，包括运动方案、营养计划、激素替代以及涉及合成代谢原理的药物策略。根据目前的数据，训练计划和药物具有很大的潜力。
