College of Pharmaceutical Science, Jilin University, Changchun, 130021, China.
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, China.
Front Med. 2018 Dec;12(6):667-677. doi: 10.1007/s11684-017-0583-y. Epub 2018 Apr 4.
Platelets have long been known to play critical roles in hemostasis by clumping and clotting blood vessel injuries. Recent experimental evidence strongly indicates that platelets can also interact with tumor cells by direct binding or secreting cytokines. For example, platelets have been shown to protect circulating cancer cells in blood circulation and to promote tumor metastasis. In-depth understanding of the role of platelets in cancer progression and metastasis provides promising approaches for platelet biomimetic drug delivery systems and functional platelet-targeting strategies for effective cancer treatment. This review highlights recent progresses in platelet membrane-based drug delivery and unique strategies that target tumor-associated platelets for cancer therapy. The paper also discusses future development opportunities and challenges encountered for clinical translation.
血小板一直以来被认为在止血过程中起着至关重要的作用，通过聚集和凝结血管损伤。最近的实验证据强烈表明，血小板还可以通过直接结合或分泌细胞因子与肿瘤细胞相互作用。例如，已有研究表明，血小板可以在血液循环中保护循环中的癌细胞，并促进肿瘤转移。深入了解血小板在癌症进展和转移中的作用，为血小板仿生药物传递系统和针对肿瘤相关血小板的功能靶向策略提供了有前途的癌症治疗方法。本文重点介绍了基于血小板膜的药物传递的最新进展，以及针对肿瘤相关血小板的独特治疗策略。本文还讨论了未来临床转化所面临的发展机遇和挑战。
