Department of General, Organic and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons, B-7000 Mons, Belgium.
Nanotechnology. 2018 Jun 29;29(26):265103. doi: 10.1088/1361-6528/aabbd0. Epub 2018 Apr 5.
Because of their outstanding magnetic properties, iron oxide nanoparticles have already been the subject of numerous studies in the biomedical field, in particular as a negative contrast agent for T-weighted nuclear magnetic resonance imaging, or as therapeutic agents in hyperthermia experiments. Recent studies have shown that below a given particle size (i.e. 5 nm), iron oxide may be used to provide a significant positive (brightening) effect on T-weighted MRI. In such an application, not only the size of the crystal, but also the control of the coating process is essential to ensure optimal properties, especially at a very high field (> 3 T). In this work, we focused on the development of very small iron oxide nanoparticles as a potential platform for high field T magnetic resonance angiography (MRA) applications. The feasibility has been evaluated in vivo at 9.4 T, demonstrating the usefulness of the developed system for MRA applications.
由于其出色的磁性能，氧化铁纳米粒子已经成为生物医学领域众多研究的主题，特别是作为 T 加权磁共振成像的阴性对比剂，或作为热疗实验中的治疗剂。最近的研究表明，在给定的颗粒尺寸（即 5nm）以下，氧化铁可用于在 T 加权磁共振成像中提供显著的正（增亮）效应。在这种应用中，不仅晶体的尺寸，而且涂层过程的控制对于确保最佳性能至关重要，尤其是在非常高的场（>3T）下。在这项工作中，我们专注于开发非常小的氧化铁纳米粒子作为高场 T 磁共振血管造影（MRA）应用的潜在平台。在 9.4T 下进行了体内可行性评估，证明了所开发系统在 MRA 应用中的有用性。
