Vangijzegem Thomas, Stanicki Dimitri, Panepinto Adriano, Socoliuc Vlad, Vekas Ladislau, Muller Robert N, Laurent Sophie
Department of General, Organic and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons, B-7000 Mons, Belgium.
Chimie des Interactions Plasma-Surface (ChIPS), University of Mons, 23 Place du Parc, B-7000 Mons, Belgium.
Nanomaterials (Basel). 2020 Apr 15;10(4):757. doi: 10.3390/nano10040757.
This study reports the development of a continuous flow process enabling the synthesis of very small iron oxide nanoparticles (VSION) intended for T-weighted magnetic resonance imaging (MRI). The influence of parameters, such as the concentration/nature of surfactants, temperature, pressure and the residence time on the thermal decomposition of iron(III) acetylacetonate in organic media was evaluated. As observed by transmission electron microscopy (TEM), the diameter of the resulting nanoparticle remains constant when modifying the residence time. However, significant differences were observed in the magnetic and relaxometric studies. This continuous flow experimental setup allowed the production of VSION with high flow rates (up to 2 mL·min), demonstrating the efficacy of such process compared to conventional batch procedure for the scale-up production of VSION.
本研究报告了一种连续流动工艺的开发，该工艺能够合成用于T加权磁共振成像（MRI）的超小氧化铁纳米颗粒（VSION）。评估了表面活性剂的浓度/性质、温度、压力和停留时间等参数对有机介质中乙酰丙酮铁热分解的影响。通过透射电子显微镜（TEM）观察发现，改变停留时间时，所得纳米颗粒的直径保持不变。然而，在磁性和弛豫测量研究中观察到了显著差异。这种连续流动实验装置能够以高流速（高达2 mL·min）生产VSION，证明了该工艺与传统间歇法相比在VSION放大生产中的有效性。
