Faculty of Chemistry, University of Wrocław, ul. F. Joliot-Curie 14, 50-383 Wrocław, Poland.
Mater Sci Eng C Mater Biol Appl. 2018 Jul 1;88:172-181. doi: 10.1016/j.msec.2018.02.007. Epub 2018 Feb 13.
Well-defined and tailor-made spherosilicates and POSS-based (POSS = Polyhedral Oligomeric Silsesquioxanes) (nano)composites with interesting chemical and mechanical properties have applications in the widely-regarded field of innovative biomaterials. They can serve as delivery systems, three-dimensional scaffolds for specific tissue engineering, biomaterials for orthopedic, cardiovascular, and reconstructive surgery, etc. Such organic-inorganic hybrids are much more effective biomaterials than pure polymers, bioglasses, metals, alloys, and ceramics currently used in medical applications and are considered as next-generation systems in innovative medical approaches. This range of applications creates a strong impetus for novel, cheap, and easy-to-scale-up methods for their synthesis. In this review (highlights since 2006), selected biomaterials consisting of various polymeric derivatives such as polymethacrylates, polylactides, polycaprolactones, polyurethanes, etc., which serve as organic side-arms of POSS and can create polymer platforms for precisely localized spherosilicates among organic matrices, are discussed as a new generation of silicon-based biosystems using spherosilicates, promising biomaterials with a particular use in soft- and hard-tissue engineering.
具有明确结构和定制化的球形硅氧烷和基于 POSS（多面体低聚倍半硅氧烷）的（纳米）复合材料具有有趣的化学和机械性能，在创新生物材料领域得到广泛应用。它们可用作递送系统、特定组织工程的三维支架、用于骨科、心血管和重建外科的生物材料等。与目前在医学应用中使用的纯聚合物、生物玻璃、金属、合金和陶瓷等相比，这种有机-无机杂化材料是更有效的生物材料，被认为是创新医学方法中的下一代系统。这种广泛的应用为其合成提供了新的、廉价且易于规模化的方法的强大动力。在这篇综述（自 2006 年以来的重点）中，讨论了由各种聚合衍生物组成的生物材料，例如聚甲基丙烯酸酯、聚乳酸、聚己内酯、聚氨酯等，它们作为 POSS 的有机侧臂，可以在有机基质中为精确局部化的球形硅氧烷创建聚合物平台，这些材料是使用球形硅氧烷的新一代硅基生物系统，是一种具有特定用途的有前途的生物材料，可用于软组织和硬组织工程。
