Dement Geriatr Cogn Disord. 2018;45(1-2):49-55. doi: 10.1159/000487131. Epub 2018 Apr 11.
BACKGROUND/AIMS: The aim of this paper was to evaluate the incremental validity of the Montreal Cognitive Assessment (MoCA) index scores and the MoCA total score in differentiating individuals with normal cognition versus mild cognitive impairment (MCI) or Alzheimer disease (AD).
Effect sizes were calculated for Alzheimer's Disease Neuroimaging Initiative research participants with normal cognition (n = 295), MCI (n = 471), or AD (n = 150).
Effect sizes for the total score were large (> 0.80) and exceeded the index scores in differentiating those with MCI versus normal cognition, MCI versus AD, and AD versus normal cognition. A combined score incorporating the Memory, Executive, and Orientation indexes also improved incremental validity for all 3 group comparisons.
Administration of the entire MoCA is more informative than the index scores, especially in distinguishing normal cognition versus MCI. A combined score has stronger incremental validity than the individual index scores.
背景/目的：本文旨在评估蒙特利尔认知评估（MoCA）指数评分和 MoCA 总分在区分正常认知个体与轻度认知障碍（MCI）或阿尔茨海默病（AD）患者方面的增量有效性。
对正常认知（n=295）、MCI（n=471）或 AD（n=150）的阿尔茨海默病神经影像学倡议研究参与者计算效应大小。
总分的效应大小较大（>0.80），并且在区分 MCI 与正常认知、MCI 与 AD 以及 AD 与正常认知方面超过了指数评分。结合记忆、执行和定向指数的综合评分也提高了所有 3 组比较的增量有效性。
整个 MoCA 的实施比指数评分更具信息量，尤其是在区分正常认知与 MCI 方面。综合评分比个别指数评分具有更强的增量有效性。
