VISN-22 Mental Illness Research Education and Clinical Center (MIRECC), VA San Diego Healthcare System, San Diego, USA.
Department of Psychiatry, University of California, San Diego, USA.
Transl Psychiatry. 2018 Apr 12;8(1):80. doi: 10.1038/s41398-018-0127-5.
Attentional dysfunction contributes to functional impairments in schizophrenia (SZ). Sustained attention is typically assessed via continuous performance tasks (CPTs), though many CPTs have limited cross-species translational validity and place demands on additional cognitive domains. A reverse-translated 5-Choice Continuous Performance Task (5C-CPT) for human testing-originally developed for use in rodents-was designed to minimize demands on perceptual, visual learning, processing speed, or working memory functions. To-date, no studies have validated the 5C-CPT against gold standard attentional measures nor evaluated how 5C-CPT scores relate to cognition in SZ. Here we examined the relationship between the 5C-CPT and the CPT-Identical Pairs (CPT-IP), an established and psychometrically robust measure of vigilance from the MATRICS Consensus Cognitive Battery (MCCB) in a sample of SZ patients (n = 35). Relationships to global and individual subdomains of cognition were also assessed. 5C-CPT and CPT-IP measures of performance (d-prime) were strongly correlated (r = 0.60). In a regression model, the 5C-CPT and CPT-IP collectively accounted for 54% of the total variance in MCCB total scores, and 27.6% of overall cognitive variance was shared between the 5C-CPT and CPT-IP. These results indicate that the reverse translated 5C-CPT and the gold standard CPT-IP index a common attentional construct that also significantly overlaps with variance in general cognitive performance. The use of simple, cross-species validated behavioral indices of attentional/cognitive functioning such as the 5C-CPT could accelerate the development of novel generalized pro-cognitive therapeutics for SZ and related neuropsychiatric disorders.
注意功能障碍导致精神分裂症（SZ）的功能障碍。持续注意力通常通过连续性能任务（CPT）进行评估，尽管许多 CPT 在跨物种的翻译中有效性有限，并对其他认知领域提出了要求。反向翻译的 5 选择连续性能任务（5C-CPT）用于人类测试-最初是为啮齿动物开发的-旨在最大限度地减少对感知，视觉学习，处理速度或工作记忆功能的需求。迄今为止，尚无研究将 5C-CPT 与注意力的黄金标准测量值进行验证，也没有评估 5C-CPT 分数与 SZ 认知之间的关系。在这里，我们研究了 5C-CPT 与 CPT-Identical Pairs（CPT-IP）之间的关系，CPT-IP 是来自 MATRICS 共识认知电池（MCCB）的一种既定的和心理测量可靠的警觉度测量方法，在 SZ 患者样本中（n=35）。还评估了与整体和个体认知子领域的关系。5C-CPT 和 CPT-IP 的性能（d-prime）测量值高度相关（r=0.60）。在回归模型中，5C-CPT 和 CPT-IP 共同解释了 MCCB 总分总方差的 54％，5C-CPT 和 CPT-IP 之间共占总认知方差的 27.6％。这些结果表明，反向翻译的 5C-CPT 和黄金标准的 CPT-IP 指数了一个共同的注意力结构，该结构也与一般认知表现的差异显著重叠。使用简单的，跨物种验证的注意力/认知功能行为指标，例如 5C-CPT，可以加速针对 SZ 和相关神经精神疾病的新型通用促认知疗法的开发。
