Department of Endocrinology, Drum Tower Hospital affiliated to Nanjing University Medical School, Nanjing, China.
Health Manager Center, Drum Tower Hospital affiliated to Nanjing University Medical School, Nanjing, China.
Sci Rep. 2018 Apr 11;8(1):5806. doi: 10.1038/s41598-018-24161-0.
This study aimed to investigate the prevalence of overweight and obesity and its relationship with cardiovascular risk diseases among different sex and age groups in an urban Chinese adult population. A retrospective analysis was performed on 384,061 Chinese adults aged 20 years and older in Nanjing. The age-standardized prevalence of overweight and obesity was 42.8% and 13.2% in men and 23.9% and 6.6% in women. A gradually increasing trend was observed in the prevalence of overweight and obesity from 2008 to 2016, especially in individuals aged 2039 years. Overweight and obesity were significantly associated with increased risks of dyslipidemia, diabetes mellitus, hypertension, and hyperuricemia. Age weakened such relationship for both genders, which spiked in individuals aged 2039 years. For men and women aged 2039 years, the OR (95% CI) of obesity reached 4.23 (4.01-4.47) and 5.29 (4.63-6.04) for dyslipidemia, 3.70 (2.97-4.60) and 6.38 (3.86-10.55) for diabetes mellitus, 6.19 (5.76-6.64) and 9.36 (7.86-11.13) for hypertension, and 3.66 (3.45-3.88) and 6.65 (5.70-7.74) for hyperuricemia, respectively. The increasing trend in the epidemic of overweight and obesity is a risk factor for cardiovascular risk diseases in Chinese adults, especially in individuals aged 2039 years.
本研究旨在调查超重和肥胖的流行情况及其与心血管疾病风险之间的关系，研究对象为南京市 20 岁及以上的 384061 名中国成年人。采用回顾性分析方法，对年龄标准化后的数据进行分析。结果显示，男性和女性的超重和肥胖的患病率分别为 42.8%和 13.2%，23.9%和 6.6%。2008 年至 2016 年，超重和肥胖的患病率呈逐渐上升趋势，尤其是 2039 岁人群。超重和肥胖与血脂异常、糖尿病、高血压和高尿酸血症的风险增加显著相关。年龄对两性的这种关系都有减弱作用，且在 2039 岁人群中作用更为明显。对于 2039 岁的男性和女性，肥胖与血脂异常的 OR（95%CI）分别为 4.23（4.01-4.47）和 5.29（4.63-6.04），与糖尿病的 OR 分别为 3.70（2.97-4.60）和 6.38（3.86-10.55），与高血压的 OR 分别为 6.19（5.76-6.64）和 9.36（7.86-11.13），与高尿酸血症的 OR 分别为 3.66（3.45-3.88）和 6.65（5.70-7.74）。超重和肥胖流行趋势的增加是中国成年人心血管疾病风险的一个危险因素，尤其是在 2039 岁人群中。
