Akbaba Gulhan, Akbaba Eren, Sahin Cem, Kara Murat
a Department of Internal Medicine, Endocrinology and Metabolism , Mugla Sitki Kocman University School of Medicine , Mugla , Turkey.
b Department of Gynecology and Obstetrics , Mugla Sitki Kocman University School of Medicine , Mugla , Turkey.
Gynecol Endocrinol. 2018 Oct;34(10):849-852. doi: 10.1080/09513590.2018.1460659. Epub 2018 Apr 12.
Our aim is to demonstrate any correlation between gestational diabetes mellitus (GDM) and polymorphism of the selenoprotein P (SEPP1) gene encoding the SEPP1 protein, having a role in the insulin resistance in GDM. Forty pregnant women with GDM and 40 healthy pregnant women were included in the study. In both groups, single nucleotide polymorphisms (SNPs), specifically, rs4987017, rs13154178, rs146125471, rs28919926, and rs16872762 were studied. There was no difference between the groups in terms of polymorphism rs146125471, rs28919926, or rs16872762 (p > .05). There was a significant difference in SNP rs13154178 polymorphism between the two groups (p < .01). When rs13154178 gene polymorphism was compared with AA homozygous individuals, fasting blood glucose levels were significantly higher in carriers of either polymorphism than in those with no polymorphism (p < .001). We suggest rs13154178 gene polymorphism may lead to GDM in the Turkish society.
我们的目的是证明妊娠期糖尿病（GDM）与编码硒蛋白P（SEPP1）的SEPP1基因多态性之间的任何相关性，该蛋白在GDM的胰岛素抵抗中起作用。40名患有GDM的孕妇和40名健康孕妇被纳入该研究。在两组中，研究了单核苷酸多态性（SNP），具体为rs4987017、rs13154178、rs146125471、rs28919926和rs16872762。在多态性rs146125471、rs28919926或rs16872762方面，两组之间没有差异（p＞0.05）。两组之间SNP rs13154178多态性存在显著差异（p＜0.01）。当将rs13154178基因多态性与AA纯合个体进行比较时，任何一种多态性携带者的空腹血糖水平均显著高于无多态性者（p＜0.001）。我们认为rs13154178基因多态性可能导致土耳其社会中的GDM。
