Department of Pharmaceutical Sciences, University of Tennessee Health Sciences Center, Memphis, TN 38163, USA.
Department of Pharmaceutical Sciences, University of Tennessee Health Sciences Center, Memphis, TN 38163, USA.
Drug Discov Today. 2018 May;23(5):992-1006. doi: 10.1016/j.drudis.2018.04.003. Epub 2018 Apr 10.
Nanomaterials that respond to externally applied physical stimuli such as temperature, light, ultrasound, magnetic field and electric field have shown great potential for controlled and targeted delivery of therapeutic agents. However, the body of literature on programming these stimuli-responsive nanomaterials to attain the desired level of pharmacologic responses is still fragmented and has not been systematically reviewed. The purpose of this review is to summarize and synthesize the literature on various design strategies for simple and sophisticated programmable physical-stimuli-responsive nanotherapeutics.
响应外部施加的物理刺激（如温度、光、超声、磁场和电场）的纳米材料在控制和靶向输送治疗剂方面显示出巨大的潜力。然而，关于编程这些刺激响应纳米材料以达到所需药理反应水平的文献仍然很零散，尚未进行系统综述。本综述的目的是总结和综合各种简单和复杂可编程物理刺激响应纳米治疗剂的设计策略的文献。
