Department of Plant Biotechnology and Bioinformatics, Ghent University, Gent, Belgium.
Center for Plant Systems Biology, VIB, Gent, Belgium.
J Exp Bot. 2018 Jun 19;69(14):3359-3372. doi: 10.1093/jxb/ery130.
Redox-dependent regulatory networks are affected by altered cellular or extracellular levels of reactive oxygen species (ROS). Perturbations of ROS production and scavenging homeostasis have a considerable impact on the nuclear transcriptome. While the regulatory mechanisms by which ROS modulate gene transcription in prokaryotes, lower eukaryotes, and mammalian cells are well established, new insights into the mechanism underlying redox control of gene expression in plants have only recently been known. In this review, we aim to provide an overview of the current knowledge on how ROS and thiol-dependent transcriptional regulatory networks are controlled. We assess the impact of redox perturbations and oxidative stress on transcriptome adjustments using cat2 mutants as a model system and discuss how redox homeostasis can modify the various parts of the transcriptional machinery.
氧化还原依赖的调节网络受到细胞内或细胞外活性氧（ROS）水平改变的影响。ROS 产生和清除的平衡失调对核转录组有很大的影响。虽然 ROS 调节原核生物、低等真核生物和哺乳动物细胞中基因转录的调节机制已经得到很好的确立，但最近才开始了解植物中氧化还原控制基因表达的机制。在这篇综述中，我们旨在概述目前关于 ROS 和巯基依赖性转录调节网络如何受到控制的知识。我们使用 cat2 突变体作为模型系统评估了氧化还原扰动和氧化应激对转录组调整的影响，并讨论了氧化还原平衡如何修饰转录机制的各个部分。
