New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, South Korea.
Department of Bionanosystem Engineering, Graduate School, Chonbuk National University, Jeonju, Republic of Korea.
J Nanobiotechnology. 2018 Apr 18;16(1):41. doi: 10.1186/s12951-018-0366-x.
Radioactive isotope-labeled gold nanomaterials have potential biomedical applications. Here, we report the synthesis and characterization of PEGylated crushed gold shell-radioactive iodide-124-labeled gold core nanoballs (PEG-I-Au@AuCBs) for in vivo tumor imaging applications through combined positron emission tomography and Cerenkov luminescent imaging (PET/CLI).
PEG-I-Au@AuCBs showed high stability and sensitivity in various pH solutions, serum, and in vivo conditions and were not toxic to tested cells. Combined PET/CLI clearly revealed tumor lesions at 1 h after injection of particles, and both signals remained visible in tumor lesions at 24 h, consistent with the biodistribution results.
Taken together, the data provided strong evidence for the application of PEG-I-Au@AuCBs as promising imaging agents in nuclear medicine imaging of various biological systems, particularly in cancer diagnosis.
放射性同位素标记的金纳米材料具有潜在的生物医学应用。在这里，我们报告了 PEGylated crushed gold shell-radioactive iodide-124-labeled gold core nanoballs（PEG-I-Au@AuCBs）的合成和表征，该纳米球可通过正电子发射断层扫描和切伦科夫发光成像（PET/CLI）进行体内肿瘤成像应用。
PEG-I-Au@AuCBs 在各种 pH 溶液、血清和体内条件下表现出高稳定性和灵敏度，并且对测试细胞没有毒性。联合 PET/CLI 在注射颗粒后 1 小时清楚地显示了肿瘤病变，并且两种信号在 24 小时时仍在肿瘤病变中可见，与生物分布结果一致。
综上所述，这些数据为将 PEG-I-Au@AuCBs 作为各种生物系统核医学成像中有前途的成像剂，特别是癌症诊断中的应用提供了有力证据。
