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1
Multispectral photoacoustic microscopy of lipids using a pulsed supercontinuum laser.使用脉冲超连续谱激光对脂质进行多光谱光声显微镜成像。
Biomed Opt Express. 2017 Dec 19;9(1):276-288. doi: 10.1364/BOE.9.000276. eCollection 2018 Jan 1.
2
Q-switch-pumped supercontinuum for ultra-high resolution optical coherence tomography.用于超高分辨率光学相干断层扫描的调Q泵浦超连续谱
Opt Lett. 2017 Nov 15;42(22):4744-4747. doi: 10.1364/OL.42.004744.
3
Development of a Fiber Laser with Independently Adjustable Properties for Optical Resolution Photoacoustic Microscopy.用于光分辨率光声显微镜的具有独立可调特性的光纤激光器的研制。
Sci Rep. 2016 Dec 8;6:38674. doi: 10.1038/srep38674.
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Contrast agents for molecular photoacoustic imaging.用于分子光声成像的造影剂。
Nat Methods. 2016 Jul 28;13(8):639-50. doi: 10.1038/nmeth.3929.
5
Bond-selective photoacoustic imaging by converting molecular vibration into acoustic waves.通过将分子振动转化为声波实现对键的选择性光声成象。
Photoacoustics. 2016 Feb 1;4(1):11-21. doi: 10.1016/j.pacs.2016.01.002. eCollection 2016 Mar.
6
High energy supercontinuum sources using tapered photonic crystal fibers for multispectral photoacoustic microscopy.用于多光谱光声显微镜的采用锥形光子晶体光纤的高能量超连续谱光源。
J Biomed Opt. 2016 Jun;21(6):61005. doi: 10.1117/1.JBO.21.6.061005.
7
Specific imaging of atherosclerotic plaque lipids with two-wavelength intravascular photoacoustics.采用双波长血管内光声成像技术对动脉粥样硬化斑块脂质进行特异性成像。
Biomed Opt Express. 2015 Aug 6;6(9):3276-86. doi: 10.1364/BOE.6.003276. eCollection 2015 Sep 1.
8
High speed intravascular photoacoustic imaging with fast optical parametric oscillator laser at 1.7 m.采用1.7μm快速光学参量振荡器激光的高速血管内光声成像
Appl Phys Lett. 2015 Aug 24;107(8):083701. doi: 10.1063/1.4929584. Epub 2015 Aug 26.
9
Near-infrared spectroscopic photoacoustic microscopy using a multi-color fiber laser source.使用多色光纤激光源的近红外光谱光声显微镜。
Biomed Opt Express. 2015 Jul 8;6(8):2819-29. doi: 10.1364/BOE.6.002819. eCollection 2015 Aug 1.
10
Photoacoustic imaging of human coronary atherosclerosis in two spectral bands.双光谱光声成像技术对人冠状动脉粥样硬化斑块的检测
Photoacoustics. 2013 Dec 5;2(1):12-20. doi: 10.1016/j.pacs.2013.11.003. eCollection 2014 Mar.

用于1650 - 1850纳米区域脂质高分辨率光谱光声成像的高脉冲能量超连续激光。

High-pulse energy supercontinuum laser for high-resolution spectroscopic photoacoustic imaging of lipids in the 1650-1850 nm region.

作者信息

Dasa Manoj Kumar, Markos Christos, Maria Michael, Petersen Christian R, Moselund Peter M, Bang Ole

机构信息

Department of Photonics Engineering, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark.

NKT Photonics A/S, Blokken 84, Birkerød 3460, Denmark.

出版信息

Biomed Opt Express. 2018 Mar 20;9(4):1762-1770. doi: 10.1364/BOE.9.001762. eCollection 2018 Apr 1.

DOI:10.1364/BOE.9.001762
PMID:29675317
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5905921/
Abstract

We propose a cost-effective high-pulse energy supercontinuum (SC) source based on a telecom range diode laser-based amplifier and a few meters of standard single-mode optical fiber, with a pulse energy density as high as ~25 nJ/nm in the 1650-1850 nm regime (factor >3 times higher than any SC source ever used in this wavelength range). We demonstrate how such an SC source combined with a tunable filter allows high-resolution spectroscopic photoacoustic imaging and the spectroscopy of lipids in the first overtone transition band of C-H bonds (1650-1850 nm). We show the successful discrimination of two different lipids (cholesterol and lipid in adipose tissue) and the photoacoustic cross-sectional scan of lipid-rich adipose tissue at three different locations. The proposed high-pulse energy SC laser paves a new direction towards compact, broadband and cost-effective source for spectroscopic photoacoustic imaging.

摘要

我们提出了一种基于电信波段二极管激光放大器和几米标准单模光纤的高性价比高脉冲能量超连续谱（SC）源，在1650 - 1850 nm波段具有高达约25 nJ/nm的脉冲能量密度（比该波长范围内以往使用的任何SC源高出3倍以上）。我们展示了这种SC源与可调谐滤波器相结合，如何实现高分辨率光谱光声成像以及C - H键第一泛音跃迁带（1650 - 1850 nm）中脂质的光谱分析。我们展示了成功区分两种不同脂质（胆固醇和脂肪组织中的脂质）以及在三个不同位置对富含脂质的脂肪组织进行光声横截面扫描。所提出的高脉冲能量SC激光器为紧凑型、宽带且经济高效的光谱光声成像光源开辟了新方向。