用于1650 - 1850纳米区域脂质高分辨率光谱光声成像的高脉冲能量超连续激光。
High-pulse energy supercontinuum laser for high-resolution spectroscopic photoacoustic imaging of lipids in the 1650-1850 nm region.
作者信息
Dasa Manoj Kumar, Markos Christos, Maria Michael, Petersen Christian R, Moselund Peter M, Bang Ole
机构信息
Department of Photonics Engineering, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark.
NKT Photonics A/S, Blokken 84, Birkerød 3460, Denmark.
出版信息
Biomed Opt Express. 2018 Mar 20;9(4):1762-1770. doi: 10.1364/BOE.9.001762. eCollection 2018 Apr 1.
Abstract
We propose a cost-effective high-pulse energy supercontinuum (SC) source based on a telecom range diode laser-based amplifier and a few meters of standard single-mode optical fiber, with a pulse energy density as high as ~25 nJ/nm in the 1650-1850 nm regime (factor >3 times higher than any SC source ever used in this wavelength range). We demonstrate how such an SC source combined with a tunable filter allows high-resolution spectroscopic photoacoustic imaging and the spectroscopy of lipids in the first overtone transition band of C-H bonds (1650-1850 nm). We show the successful discrimination of two different lipids (cholesterol and lipid in adipose tissue) and the photoacoustic cross-sectional scan of lipid-rich adipose tissue at three different locations. The proposed high-pulse energy SC laser paves a new direction towards compact, broadband and cost-effective source for spectroscopic photoacoustic imaging.
摘要
我们提出了一种基于电信波段二极管激光放大器和几米标准单模光纤的高性价比高脉冲能量超连续谱（SC）源，在1650 - 1850 nm波段具有高达约25 nJ/nm的脉冲能量密度（比该波长范围内以往使用的任何SC源高出3倍以上）。我们展示了这种SC源与可调谐滤波器相结合，如何实现高分辨率光谱光声成像以及C - H键第一泛音跃迁带（1650 - 1850 nm）中脂质的光谱分析。我们展示了成功区分两种不同脂质（胆固醇和脂肪组织中的脂质）以及在三个不同位置对富含脂质的脂肪组织进行光声横截面扫描。所提出的高脉冲能量SC激光器为紧凑型、宽带且经济高效的光谱光声成像光源开辟了新方向。
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