天然存在的芳香甾体及其生物活性。

Naturally occurring aromatic steroids and their biological activities.

机构信息

Centre for Applied Research and Innovation, Lethbridge College, 3000 College Drive South, Lethbridge, AB, T1K 1L6, Canada.

Biochemistry Lab, National Scientific Center of Marine Biology, 17 Palchevsky Str., Vladivostok, Russia, 690041.

出版信息

Appl Microbiol Biotechnol. 2018 Jun;102(11):4663-4674. doi: 10.1007/s00253-018-8968-7. Epub 2018 Apr 21.

DOI:10.1007/s00253-018-8968-7

PMID:29680899

Abstract

The present review describes the distribution and biological activities of natural mono-, di-, and triaromatic steroids. It is shown that the producers of aromatic steroids are microorganisms, fungi, and marine invertebrates, and also they were found in plants, animals, marine sediments, and karst deposits. Eighty biologically active aromatic steroids likely have an anti-tumor, anti-inflammatory, and neuroprotection activity with a confidence of 78 to 92%. The structures and predicted biological activities of aromatic steroids are available. This review emphasizes the role of aromatic steroids as an important source and potential leads for drug discovery and they are of great interest to chemists, physicians, biologists, pharmacologists, and the pharmaceutical industry.

摘要

本文综述了天然单、二和三芳甾族化合物的分布和生物活性。结果表明，芳甾族化合物的产生者为微生物、真菌和海洋无脊椎动物，也存在于植物、动物、海洋沉积物和喀斯特沉积物中。80 种具有生物活性的芳甾族化合物可能具有抗肿瘤、抗炎和神经保护活性，置信度为 78%至 92%。本文还介绍了芳甾族化合物的结构和预测的生物活性。本文强调了芳甾族化合物作为药物发现的重要来源和潜在先导化合物的作用，对化学家、医生、生物学家、药理学家和制药工业具有重要意义。